Compare and contrast the contributions of Neel, Pauling, and Ingram to our understanding of the genetic and molecular basis of sickle cell disease (SCD).

Answers

Answer 1

He demonstrated that SCD and sickle cell trait were due to the presence of abnormal 8-globin polypeptides in red blood cells. He demonstrated that the electrophhoretic mobility of B-globin from patients with SCD was different from that of healthy individuals. He demonstrated that both parents of multiple patients with SCD had low levels of sickled red blood cells. He hypothesized that SCD was a recessive trait and that the parents of patients with SCD would be heterozygous carriers. He demonstrated that the difference between B-globin polypeptides in individuals who were healthy and those with SCD is an amino acid substitution. He performed a peptide fingerprint analysis on B-globin from individuals with 84 84 and 89 88, which identified the segment of B-globin that was changed by the BS mutation. James Neel Linus Pauling Vernon Ingram

hope it helps..


Related Questions

help asap giving branlist plsss helppp

Answers

Answer:

except option 2 all of them are applied

Explanation:

If a small drop of tiny particles such as pollen grains are dropped into a drop of water on a microscope slide, they will appear to vibrate and spread out. The primary reason for this is

Answers

Answer:

The primary reason is that the pollen grains are being struck by water molecules that move in different directions. These strikes fluctuate and sometimes are uneven.

Explanation:

This vibration and spread out of molecules in water is called Brownian Motion. It is the result of the collision of small particles of water with big particles of pollen. As the particles of water move randomly hitting different sides of the pollen particle, at times, there will not be a coordinated movement, but as the movement of water particles is random, there will be moments when one side of the pollen particle will collide with more water particles, when this happens there is an unbalanced force that makes the pollen particle moves in a direction.

Hypoxia induces transcription of a DNA methyltransferase, DNMT1. What does this suggest about the relationship between hypoxia and regulation of gene expression

Answers

Answer:

Hypoxia is defined as an inherent condition of tumors that causes cancer development.

Hypoxia induces transcription of DNA methyltransferase, DNMT1 which suggest that hypoxia and regulation of gene expression have epigenetic relationship that refers to inheritable mechanisms responsible for regulating gene expression without altering the sequence of DNA bases.

DNA methylation is main epigenetic mechanism of Hypoxia.


what is a type of emigration where offspring move
away from their parents.

Answers

Answer:Dispersal

Explanation: This refers to offspring moving away from their parents. This prevents the offspring from competing with the parents for resources such as light or water. For example, dandelion seeds have “parachutes.” They allow the wind to carry the seeds far from the parents

Which of the following statements best describes the role of hormones in the body? Hormones send chemical signals throughout the body to regulate body processes.

Answers

Answer:

Hormone production and release are primarily controlled by negative feedback. In negative feedback systems, a stimulus elicits the release of a substance; once the substance reaches a certain level, it sends a signal that stops further release of the substance. In this way, the concentration of hormones in blood is maintained within a narrow range. For example, the anterior pituitary signals the thyroid to release thyroid hormones. Increasing levels of these hormones in the blood then give feedback to the hypothalamus and anterior pituitary to inhibit further signaling to the thyroid gland, as illustrated in Figure 18.14. There are three mechanisms by which endocrine glands are stimulated to synthesize and release hormones: humoral stimuli, hormonal stimuli, and neural stimuli.

Explanation:

Hyperthyroidism is a condition in which the thyroid gland is overactive. Hypothyroidism is a condition in which the thyroid gland is underactive. Which of the conditions are the following two patients most likely to have?

Patient A has symptoms including weight gain, cold sensitivity, low heart rate and fatigue.

Patient B has symptoms including weight loss, profuse sweating, increased heart rate and difficulty sleeping.Humoral Stimuli

The term “humoral” is derived from the term “humor,” which refers to bodily fluids such as blood. A humoral stimulus refers to the control of hormone release in response to changes in extracellular fluids such as blood or the ion concentration in the blood. For example, a rise in blood glucose levels triggers the pancreatic release of insulin. Insulin causes blood glucose levels to drop, which signals the pancreas to stop producing insulin in a negative feedback loop.

Hormonal stimuli refers to the release of a hormone in response to another hormone. A number of endocrine glands release hormones when stimulated by hormones released by other endocrine glands. For example, the hypothalamus produces hormones that stimulate the anterior portion of the pituitary gland. The anterior pituitary in turn releases hormones that regulate hormone production by other endocrine glands. The anterior pituitary releases the thyroid-stimulating hormone, which then stimulates the thyroid gland to produce the hormones T3 and T4. As blood concentrations of T3 and T4 rise, they inhibit both the pituitary and the hypothalamus in a negative feedback loop.

The statement that describes the role of hormones in the body is Enzymes reduce the activation energies of biological reactions.

What are hormones?

Hormones are chemicals that are secreted by the two glands, endocrine and exocrine glands.

Endocrine glands secrete hormone directly into the bloodstream, and exocrine glands are secrete hormones into ducts.

The options are attached here:

A.Enzymes aid biological reactions by providing more reactants.B.Enzymes aid biological reactions by removing products quickly.C.Enzymes raise the temperature in a cell to speed up biological reactions.D.Enzymes reduce the activation energies of biological reactions.E.Enzymes reduce the energy of products in biological reactions.

Thus, the correct option is D.Enzymes reduce the activation energies of biological reactions.

Learn more about hormones

https://brainly.com/question/13020697

#SPJ2

Which reason best explains why bacteria are good at causing infections in other organisms? It would not be able to divide. Bacteria are transmitted easily and reproduce quickly. Bacteria evolve slowly as they pass on genetic information. Bacteria are easily killed by a host’s immune system or antibiotics.

Answers

Answer:

Bacteria are transmitted easily and reproduce quickly

Explanation:

Bacteria are organisms that have a single cell. The process of reproduction of the bacteria is binary fission. The parent cell divides into the daughter cell. The DNA of the parent cell gets copied and gets divided by forming the identical daughter cells. Some bacteria have nutritional values in them while the others are infectious. They can divide at an alarming rate if they receive favorable conditions. Also, they are easily communicable and transmittable. It is because of this reason that the bacteria are good at causing infections in other organisms.

How do the products of meiosis compare to the original cell?

Answers

Answer:

Meiosis is the type of cell division in which a parent cell divides into four daughter cells. Meiosis generally occurs in the gamete or sex cells. The haploid cells are produced by the meiosis.

The original cell is diploid that contains the chromosome number (2X). The original is divided into the four daughter cell. The daughter cells produced by the meiosis contains the half chromosome number as compared with original cell (X). The crossing over occurs in meiosis and the daughter cells are quite different from the original cells.

Explanation:

What is the allele frequency?

Answers

Allel frequency, or gene frequency, is the relative frequency of an allele at a particular locus in a population, expressed as a fraction or percentage. Specifically, it is the fraction of all chromosomes in the population that carry that allele

Answer:

Explanation:

Allele frequency is the how often or what's the percentage of a particular allele in a population. Allele is referred to as version of a gene that is located on the chromosome.

For example, a gene causing death in rats might have alleles, W and w. Each would be a separate allele and the frequency would be how often or what's the percentage of W or w that is present in the population.

Suppose we are trying to find frequency of W or w allele in a population then the formula is

Allele Frequency = [# of copies of certain allele (either W or w)] / [Total number of W and w alleles]

Now suppose we have 4 WW and 2 ww in a population.

First we count up W allele then we have (4 * 2)= 8 W (we multiplied by 2 because each organism has WW, 4 WW is short of of writing WW , WW, WW, WW)Same concept for 2ww, we have total w = 2 * 2 = 4w

Total alleles = W + w = 8 +4 =12

Allele Frequency for W = 8 / 12 = 66.67%

Allle Frequency for w = 4 / 12 = 33.33%

Hope this helps!

Loyeulis,
iv. All of these
b) What do seeds need to grow into new plants?
1. Air
ii. Water
iii. Right amount of warmth
c) Potatoes grow from
iv. leaves.​

Answers

Answer:  air , water , right amount of warmth

Explanation:

Which examples show repair or replacement of damaged cells? a scrape being healed scars forming where a cut once belonged skin flaking off your arm in the winter

Answers

Answer:

Its A & B

Explanation:

a scrape being healed

scars forming where a cut once belonged

Answer:

A and B

Explanation:

i got it right on edge-

how do animals reproduce..can someone explain in detail please

Answers

Answer:

Asexual reproduction in animals occur through fission, budding,e.t.c.

Sexual reproduction starts with the combination of a sperm and egg which is called FERTILISATION.

Explanation:

The reproductive parts in animals produce gametes that fuse and form ZYGOTE.

Okay, hope it helps.

Answer:

[tex]\boxed{\mathrm{view \: explanation}}[/tex]

Explanation:

Animals should be matured to reproduce.

The animals can reproduce sexually, that involves fusion of sperm and ova inside the body.

Few animals can also reproduce asexually, asexual reproduction does not involve the fusion of gametes, the genetic material is combined to produce an offspring that has inherited the genes of the parent.

How osmosis works in the three fluid compartments of the body

Answers

Answer:

Explanation:

In the body, water moves through semi-permeable membranes of cells and from one compartment of the body to another by a process called osmosis. Osmosis is basically the diffusion of water from regions of higher concentration to regions of lower concentration, along an osmotic gradient across a semi-permeable membrane.

New mutations can also occur randomly, so there’s a chance that children of parents who didn’t inherit the gene for Huntington’s can develop a mutation in the gene that causes Huntington’s disease explain how protein synthesis contributes to the symptoms of the disease

Answers

Answer:

It depends on the mutation rate  

Explanation:

Mutations are genetic changes that occur naturally by errors during DNA replication which are not repaired by the DNA repair mechanisms. When a mutation occurs in the germline line, it may pass to the next generations and thus perpetuate itself. Huntington's disorder is an autosomal dominant disorder associated with a trinucleotide repeat mutation in the huntingtin (HTT) gene localized on chromosome 4, which encodes the Huntingtin protein. It has been shown that the high levels of Huntingtin are linked to Huntington's disorder, thereby it is believed that this mutation might be associated with a higher expression of the HTT gene.

The Lannister’s family went to bed one frigid winter night and were found deceased the next day. A squirrel’s nest was found in their chimney. What happened to the Lannisters?

Answers

Answer:

They died due to suffocation.

Explanation:

The whole Lannister’s family died due to the shortage of oxygen in the room because of squirrel’s nest in the chimney. Chimney is the only way for the removal of toxic gases and smoke produced from the burning of wood. The squirrel’s nest block the passage and the smoke and toxic gases stay in the house which causes suffocation and the whole Lannister’s family died.

The spread of cancer cells from one site to others in the body is known as _____.​

Answers

Answer:

metastasis

Explanation:

Metastasis is the process in which cancer cells break away from the place where they first formed and travel through the bloodstream to other parts of the body where they form a new tumor.

Hope that helps.

What would cause antibodies to attack the cells of the body?

Answers

Answer:

In autoimmune diseases, such as lupus, multiple sclerosis and rheumatoid arthritis, people produce antibodies that stick to their body's own proteins and attack healthy cells.

Explanation:

The diagram shows two charged objects, A and B.
Based on the field lines, what are the charges of the
objects?
3
A: positive
B: negative
O A: negative
B: positive
O A negative
B: negative
OA: positive
B: positive
A
B)
AR
NAL
Save and Fit

Answers

Answer:

A: positive

B: negative

Explanation:

Hope it helps.

Answer

A is positve and B is negitive

Explanation:

What are some changes that can occur in ecosystems?

Answers

Answer:

There are so many changes that occur in ecosystem, they are:

Habitat change. climate change. invasive species. over exploration. pollution.

Explanation:

Hope it helps you.

Seasons, tide cycles, population sizes, landscape changes, succession evolution, and climate change are instances of changes that can occur in ecosystems.

What is an ecosystem?

An ecosystem is a geographical area wherein plants, animals, and other organisms, along with weather and landscape, coexist to form a life bubble.

The instances of changes that can occur in ecosystems can be seasons, tide cycles, population sizes, landscape changes, succession evolution, and climate change.

Thus, these are some changes that can occur in the ecosystem.

For more details regarding the ecosystem, visit:

https://brainly.com/question/13979184

#SPJ2

Which statement best describes the relationship of photosynthesis and onorgy?
The process of photosynthesis is onergy storing bocause the process converts light onorgy into chemical energy,
which is stored in the bonds of glucoso,
The process of photosynthesis is onergy-releasing because the process convorts light onorgy into froo onorgy that
can be used for cell functions.
The process of photosynthesis is onergy conserving because no onergy is used throughout the process of forming
glucose and oxygen molecules,
The process of photosynthesis is onergy-wasting because photosynthesis is an inofficient process that doplotos
the cell of energy stored in the bonds of glucose.

Answers

The process of photosynthesis is onergy storing bocause the process converts light onorgy into chemical energy,

The correct answer is the first one,
The process of photosynthesis is energy storing because the process converts light energy into chemical energy,
which is stored in the bonds of glucose.

This is because photosynthesis is a storing process.

Ostriches can evade predators by running away on their powerful legs.
Please select the best answer from the choices provided
T
F

Answers

Answer:

True

Explanation:

When threatened, ostriches run away, but they can cause serious injury and death with kicks from their powerful legs. Contrary to popular belief, ostriches do not bury their heads in sand to avoid danger. This defensive behavior of lying low, so that they may appear from a distance to have their head buried.

16. Figure it shows the digestive system
С
D​

Answers

Answer:

Is there any picture or diagram to go with this question?

Place in correct order the following steps in the process of appositional growth of cartilage. a: New matrix is produced and secreted. b: Chondrocytes differentiate, each in its own lacuna. c: Stem cells undergo mitosis. d: Committed cells differentiate into chondroblasts.

Answers

Answer:

c: stem cells mitosis stem.

d: the compromised cells differentiate into chondroblasts.

a: New matrix is produced and secreted.

b: Chondrocytes differ, each in its own gap.

Explanation:

The appositional growth of cartilage occurs in an appositional order, thus generating these cartilage structures to give future bone structures or mature cartilages themselves.

In the cartilage of growth of long bones this process happens.

Chondroblasts are differentiated cells that can form the extracellular matrix, and chondrocytes would be the mature form of these that are submerged in their MEC once they reach the secretion limit.

The constant cartilage of cellular, mineral and organic structures, with organic compounds predominating (almost 80 percent are collagen fibers, proteoglycans and glycoproteins), that is why this tissue has a certain elasticity.

The following models show one large cell (A) and four small cells (B).
O
O
olo
O
00
ОО,
O
A
B.
Which of the following states why one of the models is better for moving
more nutrients in and out of the cell?
O A. A is better because it has more surface area.

Answers

The question is incomplete and the diagram is also not given. So the diagram is attached below and the complete question is as follows:

The following models show one large cell (A) and four small cells (B).

Which of the following states why one of the models is better for moving more nutrients in and out of the cell?  

A. B is better because it has more surface area.

B. A is better because it has less surface area.

C. A is better because it has more volume.

D. B is better because it has more volume

Answer:

A. B is better because it has more surface area.

Explanation:

The movement of nutrients in a cell depends on the surface to volume ratio. More is the surface to volume ratio, better will be the movement of nutrients in and out of the cell.

In the given model, small cells (B) has more surface to volume ratio as surface area of B is larger, so, the model B is better for moving more nutrients in and out of the cell.

Hence, the correct option is "A".

Answer:

B has smaller cells but more surface area than A

Explanation:

B

A new species is descovered and scientists are trying to calssify it. One of the key features found is that the species is entirely dependent on other organisms for its fodd necessary to ssutain life. What type of species is this? A. Autotrophic B. Heterotrophic C. Producer D. Mixotrophic

Answers

Answer:

B. Heterotrophic

Explanation:

Heterotrphic animals depend on other orgamisms for food. They are made of carnaviors and omnavores. They eat other animals for food.

Which of these statements best sums up evolution?
rapid change in species’ habits and features
rapid development of vestigial structures in a species
change in a population through new species being made
change in a population through genetic variation over time

Answers

Answer:

change in a population through genetic variation over time

Explanation:

took the test

which type of stem cells are most limited in differentiation

Answers

Answer:

Stem cells are the every organ and tissue that in your body.

Explanation:

The Stem cell are the many different types of the place in the body part they all are time in lives different .Stem cells are the fetal development during in the body.

Stem cells are very different  and critical abilities, cells very widely that can not do certain things.

There are many types of cells in their:- Tissue specific cells ,

Embryonic cells, Induced stem cells.

Tissue specific cell:- This types of cell are more specialized the Embryonic cells.

Embryonic stem cell:- This types of cell are obtained the inner cell in the human forms, this cells retain in the special laboratory conditions.

Induced cell:- This types of cell are developing and testing drugs.

You are a graduate student in the lab of a famous fly geneticist. You need to analyze a batch of mutant flies that were recently created in her laboratory to identify the single gene that is most likely mutated in each of the flies. Drag the mutations on the left to the appropriate blanks on the right to complete the sentences.
a. knirps (a gap gene)
b. hunchback (a gap gene)
c. hedgehog (a segment-polarity gene)
d. wingless (a segment-polarity gene)
e. kruppel (a gap gene)
f. even-skipped (a pair-rule gene)
1. Mutant fly F has predominantly lost abdominal structures, which is likely the result of a mutation in_____.
2. The wings are missing in mutant fly L, which is likely the result of a mutation in______.
3. Thoracic and abdominal structures are missing in mutant fly Q. The gene most likely responsible for this mutation is______.
4. Segment-sized sections of every other segment are missing in mutant fly Z. One likely candidate gene is_______.
5. Mutant fly X has lost the head and thorax. The gene most likely responsible for this mutation is_______.
6. The mutation observed in mutant fly O resulted in defects within the anterior or posterior regions of each segment. The gene that most likely caused this mutation is_______.

Answers

Answer:

knirps (a gap gene)

wingless (a segment-polarity gene)

kruppel (a gap gene)

even-skipped ( a pair-rule gene)

hunchback (a gap gene)

hedgehog (a segment-polarity gene)

Explanation:

The gap, segment-polarity and pair-rule genes play central roles in controlling embryonic development of arthropods. In the first place, the gap genes are associated with the formation of contiguous body segments, thereby mutations in these genes result in gaps in the normal body plan of the embryo. For example, in Drosophila melanogaster, mutations in the knirps, Krüppel and hunchback genes result in deletion of body segments. These genes are also known to regulate segment polarity genes, which determine the polarity of the embryonic parasegments by modulating Wnt and Hedgehog signaling pathways. Finally, the pair-rule genes work together with gap genes to control embryonic development of alternating body segments.

Label parts A and B in this picture of saprophytes (fungi)

Answers

Answer: A- Sporangium

              B- Rhizoids

Explanation:

the meaning of photosynthesis​

Answers

Answer: the process by which green plants and some other organisms use sunlight to synthesize foods from carbon dioxide and water. Photosynthesis in plants generally involves the green pigment chlorophyll and generates oxygen as a byproduct

Explanation:

Answer:

it is when a green plant or another plant use sunlight to synthesize food from water and carbon dioxide

:

Some organisms are made of single cells and live in the hot acidic environment of deep ocean vents.
Some organisms are single cells and live one the surface of your skin.
And there are small multicellular organisms that make fuzzy circular growth on old bread.
And of course, roses with pretty flowers are organisms.
And whales.
That’s a lot of diversity. So let’s say I think those creatures are just so different that they just couldn’t ALL be related to each other. Using specific traits, convince me that all of these organisms can be traced back to a common ancestor. (At least 6 well-chosen traits required for full credit.)
Write your answer in the essay space.

Answers

Answer:

All organisms are composed of cells that share a structural organization and play roles in similar biological processes.

Explanation:

All living organisms can be grouped in terms of cellular organization, functioning, and structure. These features enable us to define them as “subjects” of life. Organisms share basic biological mechanisms such as, among others, growth, homeostasis, development, energy processing, reproduction, etc. Moreover, life is also defined by the presence of essential biomolecules such as DNA, RNA, proteins and lipids. Finally, the cell is considered to be the basic unit of every life form, and organisms may be formed by one (unicellular) or more cells (multicellular). The fundamental feature of the cell is the presence of a membrane that separates it from the external environment, thereby defining its internal environment.

Other Questions
Select the correct answer. Read this excerpt from President John F. Kennedys inaugural address on January 20, 1961: In the long history of the world, only a few generations have been granted the role of defending freedom in its hour of maximum danger. I do not shrink from this responsibilityI welcome it. I do not believe that any of us would exchange places with any other people or any other generation. The energy, the faith, the devotion which we bring to this endeavor will light our country and all who serve itand the glow from that fire can truly light the world. And so, my fellow Americans: ask not what your country can do for youask what you can do for your country. My fellow citizens of the world: ask not what America will do for you, but what together we can do for the freedom of man. Based on the authors use of language, what is the purpose of this speech? A. to motivate people everywhere to uphold the freedom of humankind B. to motivate Americans to strive for the development of their nation C. to cultivate a sense of diversity among the American people D. to foster a feeling of happiness and unity across people and nations You have $256,000 to invest in a stock portfolio. Your choices are Stock H, with an expected return of 14.1 percent, and Stock L, with an expected return of 10.7 percent. If your goal is to create a portfolio with an expected return of 12.3 percent, how much money will you invest in Stock H and in Stock L RVLC2019] IC/OffIn AMNO, m = 20, n = 14, and mZM = 51. How many distinct triangles can be formed given these measurements?O There are no triangles possible.VXO There is only one distinct triangle possible, with m N= 33.O There is only one distinct triangle possible, with mZN 147.O There are two distinct triangles possible, with m2N 33 or mZN-147.Done) IntroDO Principles of behavior describe how behavior works, and behavior-change tactics are how applied behavior analysts put the principles to work to help people learn and use socially significant behaviors.a) trueb) false What would cause antibodies to attack the cells of the body? Lawrence recently bought a brand new Bentley Mulsanne, a very expensive car, but he is suffering from buyer's remorse. He wishes he would have bought something that made a bigger impression on the ladies at the Taco Bell drivethrough. Howard, however, recently purchased a preowned '86 Camaro with a flame job on the hood from a car dealer, and when he rolls through Taco Bell with the T-tops off, the drive-through ladies are always staring at his car and his mullet hairdo. Howard is far more satisfied with his car than Lawrence. From a marketing point of view, which of the following concepts has contributed to Howard feeling satisfied with this purchase?a. CRM implementationb. Howard's full partnership with his '86 Camaroc. Perceived value of the card. Customer loyalty why Reproduction is necessary for the survival of a species on this earth? How did the Israeli-Palestinian conflict affect Lebanon and why? Beatrice invests $1,320 in an account that pays 4 percent simple interest. How much more could she have earned over a 5-year period if the interest had been compounded annually A man walking on a railroad bridge is 2/5 of the way along the bridge when he notices a train at a distance approaching at the constant rate of 45 mph . The man can run at a constant rate in either direction to get off the bridge just in time before the train hits him. How fast can the man run? Read the text and the question and choose the right answer. Your mom is visiting Argentina and is feeling a bit tired, and she is also cold. She slept very well last night and had a good breakfast this morning, but now needs something soothing and small, which is popular in Argentina, that energizes her. What would you suggest for her to have, based on what you learned from the lesson? T Jugo Leche Agua Which of these workers is paid less than the minimum hourly wage? Bartender Electrician Hotel Manager Plumber Best medical entrance app/ book of PCB ever in a pdf in internet? Which of the following relations is not a function? x y 0 1 1 4 -1 4 x y 0 2 1 3 1 -3 x y 0 -2 1 -3 -2 5 x y 0 -2 1 -2 2 -2 CompuTop Company sells toy laptop computers for $30 each. If the variable cost for each laptop is $20 and fixed costs total $25,000, how many laptops must CompuTop sell to generate a target income of $66,667? what are documents convey information about products, processes, or business matters concisely and clearly Match the following people with their accomplishments. 1 . Stephen W. Kearney Priest responsible for building missions throughout California. 2 . Father Junipero Serra General that led an attack against Mexico City. 3 . John Slidell Colonel that established a provisional government in New Mexico. 4 . Winfield Scott Led a revolt of Californians in the Sacramento valley. 5 . John C. Fremont Sent to Mexico to negotiate the Rio Grande as the border of Texas. fill in the blank. to form a multi cellular organism, a zygote must divide many times in a process called _____. Adult stem cells are considered _________, as they can differentiate into several different cell types in the tissue where they are located. A firm has 18 senior and 22 junior partners. A committee of three partners is selected at random to represent the firm at a conference. In how many ways can at least one of the junior partners be chosen to be on the committee? Importance of social practices of nepal