g in sickle cell anemia, there is a mutation in the beta subunit of hemoglobin where a glutamic acid is replaced with valine. How would that change affect the molecule

Answers

Answer 1

Answer and explanation:

Sickle cell anemia is a type of anemia that occurs because of a mutation in the HBB gene, which codifies for the beta subunit of hemoglobin, producing an abnormal beta-globin called Hemoglobin S o HbS. This anomalous beta subunit is a product of the replacement of the amino acid glutamic acid by the amino acid valine at position 6, resulting in a beta-globin that forms a long and rigid molecule turning red blood cells shape into a sickle one, condemning erythrocytes to a premature death (which will cause the anemia). Another complication patients with sickle cell anemia can have is the blocking of blood vessels because of the abnormal and rigid shape of their red blood cells.


Related Questions


In a grassland ecosystem, what advantages does a burrower have over an animal that does not burrow?

Answers

Animals who burrow do it for a variety of reasons like nesting, hibernation, food supply and warmth. Some animals take advantage of burrows already made so they don’t have to do the digging themselves. Some only use burrows as an opportunity to ambush unsuspecting prey.
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Brendan made a diagram to compare and contrast the benefits of two types of social behavior.

The diagram shows 2 overlapping circles labeled Flocking and Herding. There is a z in Herding.

Which description belongs in the area marked "Z"?

reproduction
protection
foraging
hydrodynamic efficiency
please help this is an exam and its timeddddd

Answers

Answer:

Which description belongs in the area marked Z? Protection.

Explanation:

Have a great summer.

Herding is refer to as the act of bringing individual animals together into a group, maintaining the group, and moving the group from place to place or any combination of those.  The description belongs in the area marked "Z" is foraging. Thus, the correct option is C.

What is flocking?

A flocking is refer to as the large number of birds, especially those gathered together for the purpose of migration.  For example, a large number of animals, especially sheep or goats kept together and migrate.

Foraging behavior includes all the methods by which an animal acquires and utilizes sources of energy and nutrients. This also includes the location and resources consumption, as well as their recapture and storage, within the context of the larger community.

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A bear walks into the room. In response, you run away. Trace the events that occur from the initial release of epinephrine to the release of glucose into the blood to the generation of ATP (which ultimately leads to muscle contraction). In your answer explain the processes of a. epinephrine signal transduction leading to glucose release b. cellular respiration using glucose as the substrate and generating ATP c. acetyl choline signal transduction at the neuromuscular junction d. generation of the action potential e. muscle contraction that results

Answers

Answer:

a. Epinephrine >> G protein-coupled receptor >> cAMP >> phosphorylation of glycogen phosphorylase and glycogen synthase >> glucose

b. Cellular respiration >> glycolysis >> pyruvate oxidation >> Krebs cycle >> acetyl CoA>> oxidative phosphorylation

c and e. Acetylcholine >> nicotinic receptors >>  sodium ions (enter to the cells) >> muscular action potential >> contraction

d. Action potential >> resting potential >> potassium channels open >> sodium channels open >> threshold potential >> voltage-gated sodium channels and potassium channels open >> membrane  repolarization >> resting membrane potential (steady state of the cell)

​Explanation:

Epinephrine binds to G protein-coupled receptors, triggering the production of cyclic AMP (cAMP). cAMP is a second messenger associated with the phosphorylation of 1-glycogen phosphorylase (GP) that breaks down glycogen (the storage form of glucose) into glucose, and 2-glycogen synthase (GS), involved in the production of glycogen (i.e., phosphorylation inhibits GS activity). On the other hand, during cellular respiration, glucose is used to synthesize ATP via three sequential steps: glycolysis, Krebs cycle and oxidative phosphorylation. During glycolysis, glucose is converted into pyruvate that is subsequently oxidated into Coenzyme A (acetyl CoA), generating NADH and ATP. In the Krebs cycle, acetyl CoA is combined with the oxaloacetic acid to form citric acid, generating NADH, FADH2 and ATP. During oxidative phosphorylation, electrons from NADH and FADH2 are used to pump protons against an electrochemical concentration gradient, which is finally used to synthesize more ATP. On the other hand, during muscle contraction, acetylcholine binds to nicotinic receptors and sodium ions enter the muscle fiber, thereby generating a muscular action potential that travels across muscle cells and triggers muscle contraction when calcium ions (Ca2+) bind to the protein complex troponin by sarcomere shortening (sarcomeres are the functional units of muscle fibers). This contraction ends when Ca2+ ions are pumped back into the sarcoplasmic reticulum (a unique organelle of endoplasmic reticulum in the sarcoplasm). On the other hand, an action potential is defined as a fast and propagating change of the resting membrane potential of neuron cells. In the resting potential, potassium ion (K+) channels open, thereby K+ ions can enter/exit inside the cell. A stimulus causes the depolarization of the cell by opening Na+ channels that enter into the neuron. At the threshold potential, more sodium channels open, thereby voltage across the membrane reaches its most positive value. Subsequently, channels begin to close and more potassium channels open. Finally, the membrane repolarizes (K+ ions leave the cell) and cells return to the resting membrane potential, i.e., the steady-state of the cell.

Receptor binding motifs such as RGD have highly selective recognition for cell adhesion. Outline a strategy for incorporating a cell adhesive recognition domain to a biomaterial. Address the problems surrounding domain quantity, type, and affinity in your discussion.

Answers

Answer:

Explanation:

RGD stands for Arginine Glycine Aspartate and is a three-amino-acid peptide. It is the most extensively utilized adhesive peptide for adhering diverse cell types to a variety of biomaterials. Integrins, fibrinogen,  osteopontin, fibronectin, and bone sialoprotein, as well as collagens and laminins, all include an RGD primary binding domain. As a result, the synthetic (artificial) peptide RGD may bind to a wide range of integrin types. The artificial RGD retains its functioning through the sterilizing and processing processes of biomaterial creation because of its recognition advantage. This feature denotes the immune reactivity and pathogen transmission during xenograft.

Affinity can be modulated by the conformation of artificial RGD. The efficacy of RGD is also determined by the in vitro deposition of cells on the surface of the material sample.

The molecular processes unravel its effectiveness throughout its use as a scaffold foundation in in-vivo models. The fact that artificial RGD cannot work well in isolation is now a major aspect that defines its activity.

It has been discovered that cells release a variety of integrin-binding proteins that are more effective in activating integrin signalling than pure RGD. As a result, most biomaterials will bind and adsorb these proteins rather than RGD. As a result, a serum-free medium is employed in the majority of in vitro research.

As a result, biomaterials are supplied with RGD as well as quasi polymers such as polyethylene glycol to reduce the variance produced by native proteins. The addition of additional amino acids to RGD based on natural sequences can increase its biological activity, which can aid in the development of new tissues and the stimulation of cellular responses and signalling.

The amino terminal endpoint of the peptide, as well as the carboxyl group of the material surface, establish a covalent connection, which binds the peptide to just the surface of its biomaterial. Cell adhesion biomaterials are made from a variety of cell adhesion materials, including poly-L-lysine, mussels adhesive protein (MAP), and outer membrane (extracellular matrix) proteins.

Because MAPS are high in Dihydroxyphenylalanine and lysine, RGD is coupled with either of these to boost its cell adhesion capability. As a result, they can also aid in the attachment to damp or moist surfaces. It may also firmly adhere to glass, metals, and plastics. The addition of thiol groups to a peptide can also aid in its orientation and boost its stability.

The gap and density of this peptide sequence and structure on the biomaterial surface may be adjusted using a micro and nanotechnology (nanoscale patterning) method, which also improves ligand binding accuracy. Cellular reactions and cell activity are also under its control. Integrin receptors have been shown to be between 9 - 12 nm in size, therefore nanoscale surface patterning is crucial.

As a result, the above methods serve as a strategy for incorporating a cell adhesion recognition domain into a biomaterial while taking into account all of the technical intervention affecting its quantity, type, and affinity to the top layer for cell adhesion as a functioning tissue rather than a monolayer.

Epinephrine causes the enzyme glycogen phosphorylase to break down glycogen within a cell. Epinephrine performs this task on intact cells, meaning cells that have a membrane (not just cell contents placed in a medium). What does this fact reveal

Answers

Answer:

The fact that it reveals is that:

Epinephrine binds to the receptor tyrosine kinase on the cell membrane and does not act on glycogen phosphorylase.

Explanation:

In cellular respiration, epinephrine is a neurotransmitter and a plasma membrane hormone receptor.  It is not a lipid-derived hormone, but rather an amino acid-derived hormone. As a result, they are unable to pass through the plasma membrane of cells. They bind to receptors on the outer surface of the plasma membrane through plasma membrane hormone receptors (receptor's tyrosine kinase of the cell membrane) because they are lipid insoluble hormones.

Unlike steroid hormones, lipid insoluble hormones (epinephrine) do not directly influence glycogen phosphorylase or the target cell because they cannot enter the cell and operate directly on DNA. The activation of a signaling pathway occurs when these hormones attach to a cell surface receptor; this activates intracellular activity and performs the hormone's specific effects. Nothing crosses through the cell membrane in this fashion; the hormone that binds at the cell's surface stays at the cell's surface, while the intracellular component stays within the cell.

Which of these is not a characteristic of living things?
All living things are made up of cells.
All living things are based on a universal genetic code.
All living things move.
O All living things grow and develop.

Answers

Answer:

Not all living things move

Explanation:

Trees dont move and they are living plants.

All living things move


Explanation: Not everything that moves is living. For example if you move a tissue it is not living

solutions to stop dams

Answers

Answer:

break it down I guess

Explanation:

its a simple question and I'm pretty sure you made a typo oh well

The probability of a white chicken and a black chicken having a checkered chicken is ________
and is an example of ________

A- 50% incomplete dominance
B- 100% co-dominance
C- 100% incomplete dominance
D- 50% co- dominance

Answers

The answer is b trust me

Heredity is


A. The passing of acquired traits from parents to offspring

B. The complete analysis of the fossil record

C. The passing of traits from parents to offspring

D.The relationship between humans and bacteria​

Answers

The answer is C. Hereditary means to inherit traits from your parents.

PLS HELP FAST NO LINKS!

If you live in a region that has hot, dry summers, and cool, wet winters, what climate might you live in?

A. arid

B.temperate

C.tropical

D.Mediterranean

Answers

Answer:

Mediterranean climate

the answer would be d

atmosphere is a present around the surface of the earth but it is not present around the surface of the Moon why​

Answers

Answer:

tmosphere is a present around the surface of the earth but it is not present around the surface of the Moon because

This reduces the amount of gravity on the moon. Strong gravity is needed to hold an atmosphere into place. With weak gravity, gases that are emitted from the surface quickly are lost to outer space. Another reason is because the moon does not currently experience plate tectonics and geologic upwelling. Plate tectonics allows for a recycling of crust and convergence and divergence of plates occurs and this leads to volcanoes and gases escaping at the boundaries. The moon is said to be geologically dead.

146. The ATP/CP Pathway is best for which of the following activities? A. Running a marathon B. 100m sprint C. 30 minutes steady state cardio D. - Tabata workout​

Answers

Answer:

100m sprint

Explanation:

The ATP/CP Pathway is best for in 100m sprint activity.

what is ATP ?

Adenosine Triphosphate (ATP) is the energy carrier in every living organisms on earth which capture and store energy metabolized from food and light sources in the form of ATP.

ATP is broken down through hydrolysis during energy required by a cell, The high energy bond is broken and removal of a phosphoryl group occurred.

The energy released from this process is used to drive various cellular processes.

ATP is constantly  participates in biological reactions and central to the health and growth of all life, transfer energy from one location to another,.

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tall heterozygous pea plants were crossed and the resulting seeds grown. Out of 360 plants, 270 were tall and 90 dwarf. What describes the expected genotype resulting from the cross

Answers

Answer:

This question lacks options, the options are:

A. All 270 tall plants were heterozygous

B. All 270 tall plants were homzygous.

C. Only 90 plants were homzygous.

D. All dwarf plants were homzygous.

The answer is D.

Explanation:

This question involves a single gene coding for height in pea plants. The allele for tallness (T) is dominant over that of dwarfness (t). This means that a dwarf plant can only be homzygous recessive (tt) while a tall plant can either be homzygous (TT) or heterozygous (Tt).

According to the question, two tall heterozygous pea plants were crossed i.e. Tt × Tt. Based on this cross, a phenotypic ratio of 3:1 is expected, which is in accordance with the 270 tall plants and 90 dwarf plants (360 total) that was obtained in the cross. Since dwarfism in pea plants is a recessive trait, this means that all the dwarf plants produced in this cross (90) were homzygous (tt).

The expected genotype resulting from the cross was that all dwarf plants were purebreed.

So, according to the given information, there is a cross between Tt × Tt.  A phenotypic ratio of 3:1 is desired, which is in accord with the 270 tall plants and 90 dwarf plants (360 total) that were got in the cross.

Since dwarfism in pea plants is a different feature, this means that all the dwarf plants produced in this cross (90) were (tt).

What are the 3 principles of Mendelian genetics?

The fundamental principles of Mendelian inheritance by Mendel's three laws:

The Law of Independent Assortment,Law of Dominance, andLaw of Segregation

Thus,  the cross was that all dwarf plants were purebreed.

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2 parents one with AB blood type and one with b type can they produce a child with A blood type

Answers

Answer:

No they can not produce a child with a blood type

The graph shows atmospheric carbon dioxide levels over time.
Which two observations are most useful for explaining the trends in the data? Select two answer choices.
A. Photosynthesis and cellular respiration have opposite effects on carbon dioxide levels.
B. Carbon is stored in solid form in shells, rocks, and sediments.
C. Atmospheric carbon dioxide may dissolve in ocean water.
D. The burning of fossil fuels adds carbon dioxide to the atmosphere.
E. Activities that produce or take up carbon dioxide vary with the seasons.

Answers

Answer:

the answer is A and D

Explanation:

because yes

Cellular respiration and photosynthesis are significant carbon cycle processes. The processes via which carbon is recycled in the biosphere are known as the carbon cycle. Thus, option A, D is correct.

What is the effect of carbon dioxide to the atmosphere?

Unlike cellular respiration, which releases carbon dioxide into the environment, photosynthesis eliminates carbon dioxide from the atmosphere.

When fossil fuels are burned, a greenhouse gas called carbon dioxide is massively released into the atmosphere. Greenhouse gases, which trap heat in our atmosphere, are to blame for global warming.

Therefore, Photosynthesis and cellular respiration have opposite effects on carbon dioxide levels and the burning of fossil fuels adds carbon dioxide to the atmosphere.

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Help please! The question is in the image below

Answers

Answer: A. The cells produced sugar and oxygen during photosynthesis

Explanation: Plants today make use of this same trait, absorbing the sun's energy and air to create food (sugar) and oxygen (as a by-product)

Which of the following is superior the lungs or intestine?

Answers

I think it’s the lungs

The diagram shows the human alimentary canal. In which parts does peristalsis take place?​ plss be sure abt it

Answers

Answer:

i think answer is 3 and 4

Explanation:

peristalsis is located at esophagus and in our digestive system

The parts where peristalsis will take place are ; ( C )  parts 3 and 4

Peristalsis is a series of muscle contraction occurring in the digestive system of Humans also these series of muscle contraction can be seen in tubes connecting the human kidney and bladder as well.  

From the diagram parts 3 ( esophagus )and 4 ( intestines ) are part of the human digestive system and peristalsis is very evident in these regions in the human body.

Hence we can conclude that The parts where peristalsis will take place are  3 and 4

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proteins are made where in the cell

Answers

Answer:

Ribosomes

Explanation:

In mutualism, both organisms participating benefit from the relationship.
True or False?

Answers

Answer:

true

Explanation:

definition of human rights​

Answers

A human rights violation is the disallowance of the freedom of thought and movement to which all humans legally have a right. While individuals can violate these rights, the leadership or government of civilization most often belittles marginalized person

g About how much of the energy in the producers of an ecosystem will be available to secondary consumers in this ecosystem

Answers

Answer:

10 %.

Explanation:

Only 10 % of energy in the producers of an ecosystem will be available to secondary consumers of that ecosystem while the remaining 90 % will be lost and releases in the atmosphere in the form of heat energy. In each trophic level, only 10 % of the total biomass is transferred from one trophic level to another trophic level while the remaining biomass is released in the form of heat. If the producers has 1000 calories of energy, only 100 calories will be transferred to the primary consumer.

What percent of the organisms genetic information is the same as the genetic information of the parent PLEASE HELP FASSTTTTT

Answers

Answer:

Every person has two copies of each gene, one inherited from each parent. Most genes are the same in all people, but a small number of genes, which is less than one percent of the total are slightly different between people.

Explanation:

its also nice to keep a _______ in my purse

Answers

Answer:

its also nice to keep a __phone_____ in my purse

Explanation:

How is waste (and the accumulation of it) not only harming wildlife, but ourselves?

Answers

Not many people knew about this, but many of our waste go back into the rivers and water companies collect that water and sell it back to us!
And it has recently been on the news that a pregnant woman had micro plastics found inside the umbilical cord! Everything we drink and eat, has an 100% chance of having mini micro plastics.

Explain how the central nervous system and the peripheral system work together to keep the body activities in balance.

Answers

Answer:

Voluntary motions in the skin, bones, joints, and skeletal muscles are controlled by the somatic nervous system. Both of these PNS systems collaborate with the CNS to control physiological functions and offer responses to external stimuli.

Explanation:

The central nervous system and peripheral nervous system work together as the nerves of PNS comes out from CNS and the peripheral nervous system guide the brain and spinal cord to receive signals from the body to work.

What is the nervous system?

The nervous system is divided into two parts, the central nervous system, and the peripheral nervous system. The central nervous system consists of the brain and spinal cord. The peripheral nervous system contains all the nerves which came out from the brain and spinal cord.

Both systems work together as the nerves of the PNS connected with the brain and spinal cord. The nerves signal the brain and brain when giving signals, they travel through the nerves to the body.

Thus, together, the central nervous system and peripheral nervous system control how the brain and spinal cord receive signals from the body to function. The central nervous system sends PNS nerves out from the spinal cord.

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Gametes contain how many copies of each chromosome?

Answers

Answer:

Explanation:

each gamate carries 22 ordinary chromosome and one sex chromosome,altogether they carry 23 chromosome each.

gametes are haploid cells that contain 23 chromosomes, each of which a one of a chromosome pair that exists in diplod cells

In x linked recessive if the mother is carrier and father is normal and their first child is male and is affected the next child is female, how much chances are there that she will be carrier?

Answers

Answer:

A 50% chance I believe. The mother will always give the X chromosome and since the father is normal and doesn't carry that ressecive trait they can only get it from the mother. (I'm not completely sure!))

Answer:

50%. 50%. False

Step-by-step explanation:

Plz. Mark me. Brainliest

Define Vascular tissue?

Answers

Answer:

Vascular tissue is a complex conducting tissue found in vascular plants that is made up of several cell types. The xylem and phloem are the two main components of vascular tissue. Internally, these two tissues carry fluid and nutrients.

OAmalOHopeO

please I really need a help here ASAP. It's a physics question.

A space ship travels 3.00 ~ 10 km vertically to transport scientists from one particular station to
another. After the transportation, the captain decides to go hizontally 2.00 * 10km to visit an Orie
Calculate its:
a. Distance
b. Displacement​

Answers

Letter B, displacement

Answer:

a).Don't know if you meant to write 3x10^10km and 2x10^10km

I'll solve with this... If they aren't the values... You can then input the real values.

Distance = Total length traveled.

D= 3x10^10 + 2x10^10

D= 5x10^10Km

b) Displacement:

Since it went vertically... Then went horizontally in the second phase... It is forming a right angled Triangle and the Displacement would be the Hypotenuse of this triangle.

Disp.= √ (3x10^10)²+(2x10^10)²

Disp.=3.61x10^10km.

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