The gram-negative bacterium Vibrio cholerae produces a protein, cholera toxin (Mr 90,000), that is responsible for the characteristic symptoms of cholera: extensive loss of body water and NaCl through continuous, debilitating diarrhea. If body fluids and NaCl are not replaced, severe dehydration results; untreated, the disease is often fatal. When the cholera toxin gains access to the human intestinal tract it binds tightly to specific sites in the plasma membrane of the epithelial cells lining the small intestine, causing adenylyl cyclase to undergo prolonged activation (hours or days).

a. What is the effect of cholera toxin on [cAMP] in the intestinal cells? Why?
b. Based on the information above, suggest how cAMP normally functions in intestinal epithelial cells. Briefly justify.
c. Suggest a possible treatment for cholera

Answers

Answer 1

Answer:

a.) It causes prolonged activation of adenylyl cyclase which leads to increased levels of Cyclic adenosine monophosphate(cAMP).

b.) In the intestinal epithelial cells, the cAMP binds to the apical chloride channels and allows it to open leading to osmotic permeability of water across the cell into the lumen of the intestine which is excreted through the faeces.

C.) Cholera can effectively be treated through the use of antibiotics and intravenous fluid replacement therapy.

Explanation:

Vibrio cholerae is a gram negative rigid curved bacillus that are actively ( vigorously) motion by a polar flagellation. The name vibrio is derived from the characteristic vibration movement of the organism when viewed under a microscope. This bacteria is capable of producing toxins called cholera toxin, which it uses as a virulent factor. It is responsible for the characteristic symptoms of cholera: extensive loss of body water and NaCl through continuous, debilitating diarrhea.

Cyclic adenosine monophosphate(cAMP) which is called a second messenger because it is not a hormone that can directly institute an intracellular change, instead, it serves as a second messenger to cause an effect.In the intestinal epithelial cells, the cAMP binds to the apical chloride channels and allows it to open leading to osmotic permeability of water across the cell into the lumen of the intestine which is excreted through the faeces.

In the effect of cholera toxin on the cAMP in the intestinal cells, Cholera toxin increases the fluid loss. The binding of the toxin to the intestinal cells causes a large increase in the level of cAMP in the cells by inhibiting the conversion of GTP bound to Ga to GDP. So adenyl cyclase is not turned off and diarrhea results.

The possible treatment is through the use of antibiotics and intravenous fluid replacement therapy. Prompt and adequate replacement of lost fluid and electrolyte through oral administration and supplemented with intravenous administration of fluids highly suggested for treatment of cholera. Antibiotics is equally used for treatment only when the cholera strain has been confirmed sensitive to it through culture.


Related Questions

_____are commonly called producers



Answers

Answer:

Autotrophs

Explination: They are called this because they use the energy and simple inorganic compounds to produce organic molecules.

Each chromosome has genes that control wing shape, body color, antenna type, and eye color.

a. True
b. False

Answers

Answer:

The correct answer is - True.

Explanation:

In a simplified drosophila or fruit fly genome, Each chromosome of the homologous pair of chromosomes has the genes for the body color, wing shape, antenna type, and eye color, and all are located on the same chromosome.

So on the basis of the explanation given above it is clear that in Drosophila or fruit flies it is true that Each chromosome has genes that control wing shape, body-color, antenna type, and eye color.

Is there a human carrying capacity on Earth? Explain why or why not.

Answers

Answer: Every species has a carrying capacity, even humans. However, it is very difficult for ecologists to calculate human carrying capacity. Humans are a complex species. We do not reproduce, consume resources, and interact with our living environment uniformly.

HOPE THIS HELPS

TRUE or FALSE
Visible light has very short wavelengths.
If FALSE explain:


PLEASE HELP!!!

Thx

Answers

The answer is true: Visible light has very short wavelength

I will mark you brainlist!

What is the meaning of chaise?

A. A harness

B. A person

C. A vehicle

D. A farming tool

Answers

Answer: A ?

Explanation:

Answer:

C.

Explanation:

a horse-drawn carriage for one or two people, typically one with an open top and two wheels.

What functions are performed by the large intestine's
normal flora?

Answers

These bacteria are important in digestion and in keeping your large intestine healthy. The good bacteria that live in your colon are called your normal flora. They help prevent bad bacteria from multiplying and causing problems.

Pls help I’m failing

Answers

Answer:

C.

Explanation:

Not A. because it didn't mention that (and it's not true)

Not B. because that wasn't mentioned (and common sense tells you it incorrect)

C. because it was mentioned (differently) and it made perfect sense

Not D. because it didn't even talk about how many letters (or sounds) there was to be true (plus look at A. above)

Warm air is denser than cold air and it sinks.

A. True

B. False

Answers

Answer:

false, its less dense than air

Explanation:

Answer:

False

Explanation:

where the input molecules of respiration come from

Answers

Answer:

see the explanation

Explanation:

Most of the steps of cellular respiration take place in the mitochondria. Oxygen and glucose are both reactants in the process of cellular respiration. The main product of cellular respiration is ATP; waste products include carbon dioxide and water.

Select any true statements regarding conifers and forests. Check All That Apply Most conifer seeds can survive subzero temperatures but will be destroyed by very high temperatures. Most conifer seeds can survive subzero temperatures but will be destroyed by very high temperatures. Reforestation of a conifer forest after a wildfire can take many decades because new conifer seeds have to be brought from other areas by animals or wind.Reforestation of a conifer forest after a wildfire can take many decades because new conifer seeds have to be brought from other areas by animals or wind. Three years after a wildfire, a conifer forest will have many seedlings of the same age. Three years after a wildfire, a conifer forest will have many seedlings of the same age. Some species of conifer require fire before fertilization of their seeds can take place. Some species of conifer require fire before fertilization of their seeds can take place.

Answers

Answer:

The following are true statements regarding to conifers and forests:

O.  Most conifer seeds can survive subzero temperatures but will be destroyed by very high temperatures.

O.  Reforestation of a conifer forest after a wildfire can take many decades because new conifer seeds have to be brought from other areas by animals or wind.

O.  Some species of conifer require fire before fertilization of their seeds can take place.

Explanation:

The true statements regarding conifers and forests include the following:

Most conifer seeds can survive subzero temperatures but will be destroyed by very high temperatures- Most conifers when exposed to heat become destroyed as their viability becomes greatly reduced but can survive very low temperatures as it doesn't affect their viability.

Reforestation of a conifer forest after a wildfire can take many decades because new conifer seeds have to be brought from other areas by animals or wind- This is true as most conifers method of dispersal are through wind, animals, water etc.

Some species of conifer require fire before fertilization of their seeds can take place-  Species such as Lodgepole pine and Banksia require fire for fertilization as their cones or fruits that are completely sealed with resin.

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What produces gene flow?
ws
O mating between populations
O mutation
O geographical isolation
O speciation

Answers

Answer:

O mutation

Explanation:

please mark this answer as brainliest

CAN FISH SURVIVE ONLY IN WATER WITH DISSOLVED OXYGEN?

Answers

Answer:

Oxygen dissolves into water from two sources: the atmosphere and from plants in the water. kills fish from oxygen depletions can range from “partial” to “total”. In a partial kill the dissolved oxygen level gets low enough to suffocate sensitive species and large fish, but many small fish and hardy species survive.

Explanation:

I hope this helped you

What the answer pls science

Answers

Answer:

B

Explanation:

for someone to choke it means the person lacks oxygen in the sense that its oxygen path has been blocked so its B

The predicted values for the four phenotypes form a ratio. The simulated values match this predicted ratio.

Answers

Answer:

9:3:3:1 ; approximately

Explanation:

Just did it

What process takes place in meiosis but not mitosis?
A.
sister chromatids separating
B.
crossing over
C.
DNA replication
D.
DNA condensing into chromosomes

Answers

Answer:

A. sister chromatids separating

Answer:

will go for b. crossing over

Explanation:

"The daughter cells produced by mitosis are identical, whereas the daughter cells produced by meiosis are different because crossing over has occurred. The events that occur in meiosis but not mitosis include homologous chromosomes pairing up, crossing over, and lining up along the metaphase plate in tetrads."

3.Some plants have structures or features that protect them from harm.

If a plant has bitter-tasting leaves, what would this most likely protect the plant against?Lector inmersivo
(1 Punto)

caterpillars that would eat the plant

cold weather that would cause the plant to freeze

people who would pick the plant for its pretty flowers

hot weather that would cause the leaves to dry up

Answers

Answer:

Caterpillars that would eat the plant

Explanation:

please help me it’s due in 20 minutes

Answers

Answer:

ok

Explanation:

1. p

2. n

3. n

4. p

5. n

6. p

7.p

8. n

Visit the link below and use the information to answer the following question.

Ecological Succession: Transformation of Communities over Time

Why does secondary succession occur faster than primary succession?

Answers

Answer:

Because there is already presence of soil and nutrients in secondary succession

Explanation:

Ecological succession, which is the series of gradual change that occurs in a community over time, can be of two forms namely: primary succession and secondary succession.

- Primary succession is a kind of succession that occurs in a barren land where no form of life has existed before while secondary succession occurs on a land that has been previously colonized by certain organisms called PIONEER SPECIES, and hence, a substrate containing nutrients called SOIL for growth is available during secondary succession.

This accounts for the reason the secondary succession is faster than the primary succession because there is already presence of soil and nutrients in secondary succession.

Answer:

Soil with nutrients is already present.  Seeds are present from earlier occupants, brought in by wind, and/or germinate after fire.

Explanation:

Edge 2021

12. What is the energy released from respiration?

Answers

Answer:

Carbon Dioxide

Explanation:

During cellular respiration, glucose and oxygen are converted into carbon dioxide.

State how can go about finding the etiology of a given infectious disease? ​

Answers

Answer:

here's your answer!!

Explanation:

To diagnose such infections, doctors may use a variety of tests called immunologic tests. These tests detect one of the following: Antibodies, produced by the person's immune system in response to the microorganism. A microorganism's antigens

I hope it's helpful for you..........

An organism that survives an epidemic

Answers

Answer:

Genetic Flow is the answer but there is more than one

[15 POINTS!!]

The diagram below shows a food web.
How would the removal of the rabbit population affect the other populations in the ecosystem?

A. The field mouse population will decrease.

B. The snake population will increase

C. The lizard population will increase.

D. The tree population will decrease

Answers

Answer:

C. because the grasshopper will have less competition to eat Grass letting them reproduce more, since the grasshopper's population increases there will be more food for the lizards helping them reproduce more.

( THIS IS SCIENCE WORK ) HELP ASAP PLS I NEED HELP NO LINKS PLS
Explain in your own words the order in which the creature's traits may have evolved, starting
from the first likely trait. (Hint: Which trait is most common across the creatures?)

Answers

Answer:

Use the following key to help you complete the field study.

HINT: You can view the creatures by clicking on the link HERE.  You may also use the activity on Page 5 of the lesson in order to view them.

Step

Physical Feature

Classification

1

Smooth skin

Go to 2

Fur

Go to 3

2

One eye

Go to 4

Two eyes

Go to 5

3

One eye

Go to 7

Two eyes

Go to 8

4

Arms and legs

Silkus monowrestle

Legs only

Silkus monosquirmus

5

Arms and legs

Go to 6

Legs only

Silkus duosquirmus

6

Tail

Silkus tallyhas

No tail

Silkus stretchilus

7

Tail

Fuzzus tallywag

No tail

Fuzzus feelzalot

8

Two teeth

Go to 9

More than two teeth

Fuzzus chompilus

9

Pointy

Fuzzus pointilus

Square

Fuzzus squarilus

this is the lesson

can you heat alcohol over an open flame. Give reason for your answer​

Answers

Answer:

No, you cannot. The problem is that alcohol fumes are flammable. If you heat over an open flame you risk igniting the fumes which will start a chain reactions.

Explanation:

ggl and knowledge

The table shows data Chargaff collected on DNA nitrogenous bases in five organisms.
Percentages of Bases in Five Organisms
Source of DNA A T G C
Streptococcus 29.8 31.6 20.5 18.0
Yeast 31.3 32.9 18.7 17.1
Herring 27.8 27.5 22.2 22.6
Human 30.9 29.4 19.9 19.8
E.coli 24.7 23.6 26.0 25.7

Which statement did Chargaff conclude based on these data? Note that a letter in brackets, such as [A] or [C], refers to the concentration of one of the nitrogenous bases.
A. in DNA molecules, [T] > [A] > [G] > [C]
B. in DNA molecules [A] = [G], and [C ] = [T]
C. in DNA molecules, [A] = [T], and [C ] = [G]
D. in single-stranded DNA molecules, [A] = [T] = [C ] = [G]

Answers

Answer: in DNA molecules, [A] = [T], and [C ] = [G]

Explanation:

Which of the following statements correctly describes the relationship between erosion and deposition?

A.
Erosion breaks rocks into pieces, and deposition moves the pieces.

B.
Deposition and erosion both involve the movement of small pieces of rock from one place to another.

C.
Erosion is the movement of small pieces of rock from one place to another, and deposition is when the rock settles in a new location.

D.
Deposition and erosion break rocks into smaller pieces, but the rocks remain in place.

Answers

Answer:

I think It's A

Explanation:

I hope I helped :)

Which cell division phase is shown in the image?
A) telophase
B) metaphase
C) prophase
D) anaphase

Answers

Answer:

metaphase is the correct answer of this

Answer:

b is correct

Explanation:

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Taking two aspects of their relationship, explain how the marriage of the Prophet and Khadija set a good example for Muslim marriages today?

Answers

Answer:

Due to their behaviour towards each other.

Explanation:

The marriage of the Prophet and Khadija set a good example for Muslim marriages today because their strong relationship and respect towards each other is the key to their beautiful marriage life. In marriage life, both husband and wife has great contribution to their relationship. If both husband and wife respect each other and support in every situation of life so their relationship will be strong and they live a beautiful marriage life so we can say that the marriage life of Prophet (S.A.W) and Khadija is a good example for all Muslims.

The aquarium water and air pumped into the aquarium provide what component of an ecosystem?
А
biotic
B
abiotic
С
energy
D
decomposer

Answers

Answer: Abiotic

Explanation:

The aquarium water and air pumped into the aquarium provide an abiotic component of an ecosystem. Therefore, option B is correct.

What are ecosystems and their components?

A biological community of living things that interacts with the surrounding environment and other nonliving elements is referred to as an ecosystem. It can also be described as the series of interactions or communications between living things and their surroundings.

There are two parts to any ecosystem: biotic and abiotic components. Abiotically refers to non-living items, whereas biotic components refer to all live organisms in ecology. The equilibrium in the environment is maintained by these biotic and abiotic interactions.

Thus, the aquarium water and air pumped into the aquarium provide an abiotic component of an ecosystem. Therefore, option B is correct.

Learn more about an ecosystem, here:

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Plsss help got to submitted today

Answers

Answer:

One interaction is between the deer and the grass the deer eats the grass and energy is transferred and then the mountain lions eats the deer and the deer's energy is transferred to the mountain lion

Explanation:

hears your answer :D

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