What type of transport occurs in the cell membrane when a person does sports and is consuming alcohol?

Answers

Answer 1

Cellular transport: it is the exchange of substances through the plasma membrane, which is a semipermeable membrane. Transport routes are through the cell membrane

It allows the metabolism waste to be expelled from its interior It allows the movement of substances that it synthesizes as hormones. Metabolic energy: is the way in which it acquires nutrients through processes of incorporation into the cell of nutrients dissolved in water.

Therefore, when the person consumes alcohol in excess the ce transport is part of the disincorporation of toxic waste, while when the person does sports, and is supposed to have a balanced diet, the cellular transport uses it for his metabolic energy.


Related Questions

For a type of cat, short whiskers are dominant (S) and long whiskers are
recessive (s). The Punnett square below shows a cross between two cats.
What is the phenotype ratio for this cross?
sls
sssss
S
Ss
SS
A. O short, 4 long
B. 3 short, 1 long
C. 2 short, 2 long
D. 4 short, 0 long

Answers

The correct answer is option D) 4 short, 0 long.

What is the phenotype ratio?

A phenotypic ratio is a quantitative relation between phenotypes showing the number of times the frequency of one phenotype correlates with another. When a researcher would like to obtain the gene expression for generations of an organism, they use the phenotypic ratio obtained from a test cross.

What is the phenotype ratio example?

There are two dogs that are heterozygous for black coat color. In this breed, black fur is dominant over white fur. Thus, heterozygous dogs and homozygous dominant dogs have the same phenotype of black fur and homozygous recessive individuals have white fur.

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Answer:

C. 2 short, 2 long

Explanation:

Hypoxia induces transcription of a DNA methyltransferase, DNMT1. What does this suggest about the relationship between hypoxia and regulation of gene expression

Answers

Answer:

Hypoxia is defined as an inherent condition of tumors that causes cancer development.

Hypoxia induces transcription of DNA methyltransferase, DNMT1 which suggest that hypoxia and regulation of gene expression have epigenetic relationship that refers to inheritable mechanisms responsible for regulating gene expression without altering the sequence of DNA bases.

DNA methylation is main epigenetic mechanism of Hypoxia.

4: Units of inheritance known as genes exist in pairs.
a) TRUE
b) FALSE
5: A tall plant (AA) is crossed with a short plant (aa). The offspring produced in Fl will be
a) all Tall
b) short
c) y tall and 72 short
d) no of the above
6: The genotypes (or genotypic ratio) of the Fl offspring in 5 will be
a) all Aa (correct)
b) 12 AA, 12 Aa
c) aa
d) none of the above.
7: Alternate forms of genes are called alleles.
a) TRUE
b) FALSE
8: Phenotypes are
a) physical characteristics determined by genes
b) genes
c) genetic characteristics
d) alleles
9: The inheritance law known as the Law of segregation was postulated by
a) Mendel
b) Aristotle
c) Morgan
d) Darwin
10: Heterozygous organisms carry one dominant and one recessive allele​

Answers

Answer:

4. a

5. a

6. a

7. a

8. a

9. a

10. True

Explanation:

4. Units of inheritance in living organisms are known as genes. These genes exist in pairs in all organisms and a copy of each gene is passed down to the offspring during reproduction.

Correct option: a

5. Assuming the dominance of allele A over allele a:

                AA    x    aa

          Aa    Aa    Aa    Aa

All the offspring will appear tall since the effects of allele a is masked by allele A.

Correct option: a

6. From the cross in (5) above, the genotypic ratio of the offspring is 100% Aa.

Correct option: a

7. Alternate forms of genes in living organisms are known as alleles. A copy of the alleles is usually passed down to the offspring during the process of reproduction.

Correct option: a

8. Phenotypes are the physical appearance of organisms. They are physical interpretation of genes.

Correct option: a

9. The law of segregation was postulated by Gregor Mendel. It states that gene pairs segregate during the process of meiosis and then randomly unite during the process of fertilization.

Correct option: a

10 Heterozygous organisms have two different alleles for the same genes. For genes that obey Mendelian laws, heterozygous condition is characterized by one dominant and one recessive alleles.

Natural proteins most commonly contain linear polypeptides between 100 and 1000 residues in length. One of the reasons polypeptides outside this range may be disfavored is that

Answers

B) smaller polypeptides do not form stable folded structures.

How can changes on earths surface affect changes below surface

Answers

Answer:

There are several changes that occur on the earth's surface but also affects the changes below the surface, some of them are as follows:

When rainfall occur on the sandy surface on earth, it looses the soil under the surface and can cause landslides.Imbalance in the food chain above or on the earth surface can affect the nutrient quantity below the surface that is essential for soil bacteria and other microorganisms.Deforestation can also loosen the soil and soil under surface can shift its position.Use of chemicals on agriculture surface can lead to change the fertility of soil below the surface.

A new species is descovered and scientists are trying to calssify it. One of the key features found is that the species is entirely dependent on other organisms for its fodd necessary to ssutain life. What type of species is this? A. Autotrophic B. Heterotrophic C. Producer D. Mixotrophic

Answers

Answer:

B. Heterotrophic

Explanation:

Heterotrphic animals depend on other orgamisms for food. They are made of carnaviors and omnavores. They eat other animals for food.

Which examples show repair or replacement of damaged cells? a scrape being healed scars forming where a cut once belonged skin flaking off your arm in the winter

Answers

Answer:

Its A & B

Explanation:

a scrape being healed

scars forming where a cut once belonged

Answer:

A and B

Explanation:

i got it right on edge-

Since viruses are typically 20-200nm in diameter.. what is the best microscope to view them?

Answers

Answer:

electron microscope

Explanation:

Due to their extremely small size, the best microscope to view viruses would be the electron microscope.

The electron microscope has the capability to create resolved images of extremely small objects by utilizing electrons as a source of light instead of the visible light photon that is typical of light microscopes.

There are different two types of electron microscopes:

the scanning electron microscope, andthe transmission electron microscope.

A typical scanning electron microscope creates an image of an object by detecting knock-off electrons from the object, whereas a transmission electron microscope uses electrons that pass through the object to create the image of the object.

Yellow dung flies (Scathophaga stercoraria) are diploid organisms with 12 chromosomes in their diploid cells. Without taking into account recombination, how many different genetic gametes can this fly generate based on the arrangement of its chromosomes in the metaphase plate during meiosis

Answers

In the given case, the sum of the number of gametes possible in the fruit fly is 2¹² or 4096.  

Determination of the number of genetic gametes:

At metaphase I, the arrangement of chromosomes takes place at the equatorial plate and at the equator, the orientation of homologous pairs takes place randomly. This orientation helps in finding the genes found within a gamete as each of the gametes will get only one chromatid of a chromosome.  

Now by independent assortment, the variation occurs within the gametes, which suggests that the alleles of distinct genes separate independently from one another at the time of cell differentiation. Due to independent assortment, the number of different kinds of gametes possible within the chromosomes can be determined by using the formula, 2ⁿ, where n is the number of chromosomes present within a set.  

Thus, based on the given information, the number of chromosomes present in a fruit fly is 12. Thus, the sum of the number of gametes possible in the mentioned fruit fly is 2¹² or 4096.  

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Define feeding of living things ​

Answers

Explanation:

the process by which the organism obtsin their their food is called feeding of living thing.

Answer:

Explanation:

Feeding is the process by which organisms, typically animals, obtain food. Terminology often uses either the suffixes -vore, -vory, -vorous from Latin vorare, meaning "to devour", or -phage, -phagy, -phagous from Greek φαγεῖν (phagein), meaning "to eat".

Environmental engineers minimize the impact of land development on the environment.
Please select the best answer from the choices provided
t or f​

Answers

The correct answer is True

Explanation:

The focus of environmental engineering is to create technologies and solutions to prevent environmental pollution and destruction, and in this way protect human societies, as well as, natural ecosystems. This includes solutions to reduce the impact of land development that involves altering natural ecosystems to build houses and other human constructions. In this area, environmental engineers make the use of land for humans efficient and create models that are more friendly to the environment. Thus, the statement is true.

Answer:

T R U E

Explanation:

just took the test on and got it right

A certain strain of E. coli is constitutive for the enzymes for lactose metabolism. On an F' plasmid you have the choice of adding one (but only one) element of the lac system to make the bacteria a merodiploid for that element. Assume the original E. coli has wild-type structural loci. If your goal is to determine whether the lac operon is constitutive because of a mutant regulator OR because of a mutant operator, which one wild-type element of the lac operon would you add using sexduction?
a. operator region
b. regulator (repressor)
c. gene promoter region
d. structural genes

Answers

Answer:

The correct option is B: regulator (repressor)

Explanation:

A regulator gene would be required to control the expression by either increasing or decreasing the transcription of that particular gene. In doing so, the amount of protein product made by the gene can be regulated. In the wild-type case, the gene lacl is responsible for generating the mRNA which translates to a Lac repressor protein that binds at the operator region.

16. Figure it shows the digestive system
С
D​

Answers

Answer:

Is there any picture or diagram to go with this question?

Organisms inherit specific traits and characteristics from their parents.

Answers

Answer:

True

Explanation:

It gets passed doen like one dominant brown eye and a recessive blue eye. most likley the brown would be passed down.  

Ostriches can evade predators by running away on their powerful legs.
Please select the best answer from the choices provided
T
F

Answers

Answer:

True

Explanation:

When threatened, ostriches run away, but they can cause serious injury and death with kicks from their powerful legs. Contrary to popular belief, ostriches do not bury their heads in sand to avoid danger. This defensive behavior of lying low, so that they may appear from a distance to have their head buried.

cm
If a plate moves at a rate of 3 toward
year
the north, where would the plate be in 5,000
years? Express your answer in meters.

Answers

Answer

150 metres

Explanation

The plate moves at a rate of 3cm/year

In 5000 years, the plate would have moved:

3cm • 5000 = 15000 cm

Convert from cm to m (100cm = 1m)

15000 / 100 = 150

Answer is therefore 150 metres

In the microarray analysis some genes, such as ERB-B2 and ESR1, have been found to be associated with particular disease or conditions such as cancer. Other genes, such as the ABC-B2 gene, are not associated with a disease but are involved in resistance to certain drugs or treatments. Why would it be useful to test for the expression of genes like the ABC-B2 gene on the microarray

Answers

Answer:

The expression of genes associated with drug resistance leads to the reduction in the effectiveness of drugs against cancer cells.

Explanation:

In cancer, drug resistance is produced when oncogenic cells are able to develop mechanisms of resistance against drugs such as, for example, chemotherapeutic agents. In these cases, therapeutic treatments become ineffective to fight against cancer cells and tumor progression. In consequence, it is imperative to trace the expression of target oncogenes associated with drug resistance in order to provide effective treatments to eliminate cancer cells.

What are some changes that can occur in ecosystems?

Answers

Answer:

There are so many changes that occur in ecosystem, they are:

Habitat change. climate change. invasive species. over exploration. pollution.

Explanation:

Hope it helps you.

Seasons, tide cycles, population sizes, landscape changes, succession evolution, and climate change are instances of changes that can occur in ecosystems.

What is an ecosystem?

An ecosystem is a geographical area wherein plants, animals, and other organisms, along with weather and landscape, coexist to form a life bubble.

The instances of changes that can occur in ecosystems can be seasons, tide cycles, population sizes, landscape changes, succession evolution, and climate change.

Thus, these are some changes that can occur in the ecosystem.

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46:11
The diagram shows an animal cell.
Which letter marks the location where carbon dioxide
is produced during respiration?
W
Х
Y
Z

Answers

I can’t see the image but CO2 is produced in the mitochondria during respiration

The mitochondria looks like this:

The respiratory system allows for gas exchange to happen in the lungs. How do the respiratory and cardiovascular systems interact?

Answers

Well, the respiratory system is responsible for bringing oxygen into the body. Blood passes in capillaries in the lungs and picks up the oxygen. Blood carries oxygen to different parts of the body. Then the blood take carbon dioxide, a waste gas, back to the lungs. Then the lungs expel the carbon dioxide when you exhale.

Happy to help!

There are two primary models of the universe. One is the expanding model, which says that the universe is constantly increasing in size. The other is, the steady state model, which says that the universe is approximately constant in size and shape. What evidence would you expect to see if the expanding model were correct?

Answers

Answer:

Ok, suppose that the universe is expanding:

If the universe is expanding, then the distance between "fixed" points in the universe (we can set the fixed points as planets, galaxies, etc) would change with the time.

This means that, if the distance between the Earth and a given star or planet (that is not in our nearby region) should change as time goes by.

Now, this was actually observed:

There is something called the doppler effect:

In a short way, if an object is moving away, the light that comes from that object will have a red shift (it seems a little more reddish than it actually is)

If the object is moving towards us, the light that comes from the object will have a blue shift (it seems a little more blueish than it actually is)

Those shifts can be observed from the Earth, so from that is safe to conclude that the expanding model is actually correct.

Answer:

Observing objects in the sky that gradually move away from Earth could prove that the expanding model is correct.

Explanation:

Which of the following statements best describes the role of hormones in the body? Hormones send chemical signals throughout the body to regulate body processes.

Answers

Answer:

Hormone production and release are primarily controlled by negative feedback. In negative feedback systems, a stimulus elicits the release of a substance; once the substance reaches a certain level, it sends a signal that stops further release of the substance. In this way, the concentration of hormones in blood is maintained within a narrow range. For example, the anterior pituitary signals the thyroid to release thyroid hormones. Increasing levels of these hormones in the blood then give feedback to the hypothalamus and anterior pituitary to inhibit further signaling to the thyroid gland, as illustrated in Figure 18.14. There are three mechanisms by which endocrine glands are stimulated to synthesize and release hormones: humoral stimuli, hormonal stimuli, and neural stimuli.

Explanation:

Hyperthyroidism is a condition in which the thyroid gland is overactive. Hypothyroidism is a condition in which the thyroid gland is underactive. Which of the conditions are the following two patients most likely to have?

Patient A has symptoms including weight gain, cold sensitivity, low heart rate and fatigue.

Patient B has symptoms including weight loss, profuse sweating, increased heart rate and difficulty sleeping.Humoral Stimuli

The term “humoral” is derived from the term “humor,” which refers to bodily fluids such as blood. A humoral stimulus refers to the control of hormone release in response to changes in extracellular fluids such as blood or the ion concentration in the blood. For example, a rise in blood glucose levels triggers the pancreatic release of insulin. Insulin causes blood glucose levels to drop, which signals the pancreas to stop producing insulin in a negative feedback loop.

Hormonal stimuli refers to the release of a hormone in response to another hormone. A number of endocrine glands release hormones when stimulated by hormones released by other endocrine glands. For example, the hypothalamus produces hormones that stimulate the anterior portion of the pituitary gland. The anterior pituitary in turn releases hormones that regulate hormone production by other endocrine glands. The anterior pituitary releases the thyroid-stimulating hormone, which then stimulates the thyroid gland to produce the hormones T3 and T4. As blood concentrations of T3 and T4 rise, they inhibit both the pituitary and the hypothalamus in a negative feedback loop.

The statement that describes the role of hormones in the body is Enzymes reduce the activation energies of biological reactions.

What are hormones?

Hormones are chemicals that are secreted by the two glands, endocrine and exocrine glands.

Endocrine glands secrete hormone directly into the bloodstream, and exocrine glands are secrete hormones into ducts.

The options are attached here:

A.Enzymes aid biological reactions by providing more reactants.B.Enzymes aid biological reactions by removing products quickly.C.Enzymes raise the temperature in a cell to speed up biological reactions.D.Enzymes reduce the activation energies of biological reactions.E.Enzymes reduce the energy of products in biological reactions.

Thus, the correct option is D.Enzymes reduce the activation energies of biological reactions.

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Reptiles are closely related to birds. Which of the following characteristics do birds and reptiles share?

Answers

They share many characteristics such as scales on parts of their bodies and they lay eggs. They also very well can share having beaks too.

New mutations can also occur randomly, so there’s a chance that children of parents who didn’t inherit the gene for Huntington’s can develop a mutation in the gene that causes Huntington’s disease explain how protein synthesis contributes to the symptoms of the disease

Answers

Answer:

It depends on the mutation rate  

Explanation:

Mutations are genetic changes that occur naturally by errors during DNA replication which are not repaired by the DNA repair mechanisms. When a mutation occurs in the germline line, it may pass to the next generations and thus perpetuate itself. Huntington's disorder is an autosomal dominant disorder associated with a trinucleotide repeat mutation in the huntingtin (HTT) gene localized on chromosome 4, which encodes the Huntingtin protein. It has been shown that the high levels of Huntingtin are linked to Huntington's disorder, thereby it is believed that this mutation might be associated with a higher expression of the HTT gene.

Which blood type can be transfused into a patient who has blood type A–?

Answers

Answer:

o negative

Explanation:

how do animals reproduce..can someone explain in detail please

Answers

Answer:

Asexual reproduction in animals occur through fission, budding,e.t.c.

Sexual reproduction starts with the combination of a sperm and egg which is called FERTILISATION.

Explanation:

The reproductive parts in animals produce gametes that fuse and form ZYGOTE.

Okay, hope it helps.

Answer:

[tex]\boxed{\mathrm{view \: explanation}}[/tex]

Explanation:

Animals should be matured to reproduce.

The animals can reproduce sexually, that involves fusion of sperm and ova inside the body.

Few animals can also reproduce asexually, asexual reproduction does not involve the fusion of gametes, the genetic material is combined to produce an offspring that has inherited the genes of the parent.

Drag each tile to the correct box.
Lucia is walking barefoot in her yard. She accidentally steps on a nail. How will her nervous system work to generate a reaction? Arrange the events chronologically.

Answers

Complete question:

Drag each tile to the correct box.

Lucia is walking barefoot in her yard. She accidentally steps on a nail. How will her nervous system work to generate a reaction? Arrange the events chronologically.

Interneurons relay the impulse to motor neurons in the spinal cord.She immediately moves her foot. The sensory neuron generates an impulse. Receptors in her toe receive stimuli. Motor neurons signal the leg muscles.

Answer:

4. Receptors in her toe receive stimuli

3. The sensory neuron generates an impulse.  

1. Interneurons relay the impulse to motor neurons in the spinal cord.

5. Motor neuron signal the leg muscles    

2. She immediately moves her foot.  

Explanation:

The reflex arc refers to an action mechanism that responds to different stimuli.  It is an involuntary reaction involving different nervous vias. The reflex arc is composed of receptors, afferent nervous fibers, efferent nervous fibers, and effectors.    

Receptors are located in nervous terminals and are widely distributed in the organism. Receptors are capable of receiving stimuli from different nature, and most of them are specialized in one kind of stimuli such as vision, audition, touch, among others. In the exposed example, these sensory receptors were located in the toe, and probably they were touch receptors.

When they receive the stimulus the sensory neuron transforms it into an excitatory nervous impulse that goes to the central nervous system along the afferent nerves. This stage is known as the afferent via, beginning with the environmental information received by sensory receptors, and ending in the arrival of the transcripted message to the central nervous system.

When the central nervous system receives the information, it processes it and sends an appropriate answer according to the stimulus. The message goes along the interneurons to the motor fibers, which are in charge of taking that answer to its destiny, the effectors. Effectors are usually muscles or glands, and they transform the received impulse into a motor answer that executes the reflex action. In the exposed example, the effector in the muscle. This stage is known as the efferent via, beginning in the central nervous system sending an answer impulse and ending in the effector (muscle) executing the answer.

Answer:

Receptors in her toe receive stimuli.

The sensory neuron generates an impulse.

Interneurons relay the impulse to motor neurons in the spinal cord.

Motor neurons signal the leg muscles.

She immediately moves her foot.

Explanation:

right on edMentum

Why is it important to classify the millions of species on Earth? to have common names that everyone can remember to more easily sequence their genetic material to devise scientific names that only scientists can learn to organize them and speak about them accurately

Answers

Answer:

to organize them and speak about them accurately.

Explanation:

organisms are classified to understand the relationships between all living things.

Answer:

D

Explanation:

Which joint performs adduction, abduction, horizontal adduction and abduction, medial and lateral rotation, and circumduction?

Answers

Answer:

The ball and socket joint is the one that can perform all those movements.

Explanation:

Ball and socket joint, also know as spheroid joint are types of joints where the part of the bone that articulates with the other bone has a spheroidal shape or ball shape that fits in the depression of the other bone, which means that they are a synovial enarthrosis joint. It has a wide range of movements because it can move in the transverse, vertical, and sagittal axes. An example of this joint is the shoulder, between the scapula and the humerus.

Answer: Sholder and hip

Explanation:

Why is it important to classify the millions of species on Earth? to have common names that everyone can remember to more easily sequence their genetic material to devise scientific names that only scientists can learn to organize them and speak about them accurately

Answers

Answer:

to organize them and speak about them accurately

Explanation:

There are millions of species that exist on Earth. Many of them are yet to be discovered. They are named and classified into specific groups. This helps in organizing each specie according to the characteristics, and traits. The classification is done to show the hierarchy and focuses on the relationships that the organisms possess with other organisms about evolution. Classification helps in identifying and analyzing any specific specie accurately and particularly.

Answer:

The answer is D.

Explanation:

The first person who answered this was correct.

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Which expression can you simplify by combining like terms?CLEAR CHECK12b2+4ab3ba617a26b2a+4ba95b25a2+8ab14a2+6ab3b3a Tyler is 14 years old. He has just been expelled from school for bringing a knife. He has been arrested on two previous occasions - once for beating up another boy very badly and another time for setting fire to his neighbor's barn. Tyler's parents are at their wit's end and don't know what to do. According to the DSM-5 Tyler would likely be diagnosed with: a. Antisocial Personality Disorder b. Conduct disorder c. Oppositional defiant disorder d. Psychopathy Plz help me 3(x + 1) = 5 + x Briefly explain what was done in the experiment where pigeons could choose which button to peck in the Skinner box. How does this relate to self-control? Cynthia invested $12,000 in a savings account. If the interest rate is 6%, how much will be in the account in 10 years by compounding continuously? Round to the nearest cent. If you have completely polarized light of intensity 125 W/m2, what will its intensity be after passing through a polarizing filter with its axis at an 89.5 angle to the light's polarization direction? Drag the tiles to the correct boxes to complete the pairs. Not all tiles will be used. Consider the functions given below. VIEW FILE ATTACHED did Catchings respond not having aprofessional women's league to play in?AShe planned to play in the boys'league.BShe was sad that she couldn't playin a leagueShe planned to start her ownleague team.DShe gave up on her dream of goingpro Brad wants to open a new savings account. He finds one that returns 3% on his investment each year.Question 1Assign a variable to each of the following peces of information: final balance initial investment return rateuse the variable to write a formula for the final balance after 2 years Please help me as fast as you can. thanks Which statement best describes the relationship of photosynthesis and energy? 1. The process of photosynthesis is energy-storing because the process converts light energy into chemical energy, which is stored in the bonds of glucose. 2.The process of photosynthesis is energy-releasing because the process converts light energy into free energy that can be used for cell functions. 3.The process of photosynthesis is energy-conserving because no energy is used throughout the process of forming glucose and oxygen molecules. 4.The process of photosynthesis is energy-wasting because photosynthesis is an inefficient process that depletes the cell of energy stored in the bonds of glucose. The table below gives the numbers of protons, electrons, and neutrons in four atoms.Atom112Number of protons3940|3940Number of electrons39403940Number of neutrons525015451314Based on the information that is given, which atom in the table has the highest mass?O 123 The diameter of a circle is 3.5 inches. What is the circumference of the circle? Intntalo!Fill in the blanks Activity Textbook InstructionsWrite sentences using the present progressive with the information provided. Follow the model. how to solve this problem:If a borrower can afford to make monthly principal and interest payments of $1,000 and the lender will make a 30-year loan at 5-1/2%, or a 20-year loan at 4-1/2%, what is the largest loan (rounded to the nearest $100) this buyer can afford? Greenbrier Industrial Products' bonds have a 7.60 percent coupon and pay interest annually. The face value is $1,000 and the current market price is $1,062.50 per bond. The bonds mature in 16 years. What is the yield to maturity Can you cure a virus? Can you cure a bacteria? Can you cure a fungus? Micah is handing out miniature chocolate bars and butterscotch hard candies for Halloween. He wants tohave a total of 7 pounds of candy, but he doesn't want to spend more than $11.00 total on the candy. If miniature chocolate bars costs $1.80 per pound, and butterscotch hard candies costs $1.00 per pound, how many pounds of each type of candy should he buy? John wants to nail a thumbtack on his circular board, pictured below. If the thumbtack is equally likely to be placed anywhere on the board, what is the probability that the thumbtack will be placed on the inner circle? Use 3.14 for pi , and round your answer to the nearest whole percent. A. 51% B. 55% C. 57% D. 60% There is a bag with only red marbles and blue marbles. The probability of randomly choosing a red marble is 7 9 . There are 28 red marbles in the bag and each is equally likely to be chosen. Work out how many marbles in total there must be.