Answer:
Nuclear division will not occur in that cell
Please find the explanation below
Explanation:
Mitosis is a type of cell division in which two genetically identical daughter cells form from a single cell. The mitotic process occurs in stages, which includes the PROMETAPHASE described in this question. Prometaphase is the second stage of mitosis i.e after prophase and before metaphase.
Prometaphase stage is characterized by the degradation of the nuclear envelope in order to allow the sister chromatids to be separated into opposite poles. Also, a protein called KINETOCHORE forms at the centromere in order for the microtubules to attach to them in subsequent stages.
If an inhibitor is introduced into the cell at PROMETAPHASE stage, the activities described above, which are important for the separation of the chromatids, will not occur. Hence, the likely effect on the cells is INABILITY of NUCLEAR DIVISION TO OCCUR.
The most likely outcome of the addition of an inhibitor to Aurora B in prometaphase of a cell undergoing mitosis is the fact that sister chromatid arms would not separate (Option B).
Aurora B is a crucial regulator of accurate mitosis that localizes to the chromosomes during prophase, the centromeres during metaphase, and the mitotic spindle during anaphase.During prometaphase, this protein (Aurora B) regulates the association of motor proteins with the kinetochore, which s a structure associated with duplicated chromatids in eukaryotic cells.The interactions of the kinetochores with microtubules of the mitotic spindle modulate the movement of chromosomes during prometaphase and metaphase, and subsequent segregation during anaphase.In conclusion, the most likely outcome of the addition of an inhibitor to Aurora B in prometaphase of a cell undergoing mitosis is the fact that sister chromatid arms would not separate (Option B).
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