Serpins are naturally occurring proteins that serve as serine protease inhibitors. Serpins bind to the enzyme and are cleaved, but the acyl enzyme intermediate cannot behydrolyzed leading to irreversible inhibition. One of the serpins is a potent inhibitor of the serine protease trypsin and, as expected, contains an arginine at the site of cleavage. Using arrows to show the flow of electrons, draw the mechanism for theinhibition of trypsin by this serpin, labeling all intermediates. Draw the side chains of important enzyme amino acids, and show all hydrogen bonding within the enzyme-substrate complex. Also be sure to include the important arginine on the inhibitor including its side chain.
Answers
Answer:
Explanation:
The serpins are components of human plasma and its mutations result in numerous genetic diseases, such as caused by the deficiency of α 1 -antitrypsin. They are proteins of high molecular mass (350-500 amino acids) and have been identified in numerous organisms, from viruses to mammals. The serpins interact with the target enzyme by a similar mechanism on a substrate, although an irreversible interaction where the bond occurs serpin adopts different conformations to interact with the protease target, causing a deformation of the active site of the protease.
The mechanism of inhibition of Trypsin by serpin can be seen in the image below.
Related Questions
A group of researchers are monitoring the health of a salt marsh. They
measure high levels of nitrates and phosphates in the sediment of the marsh
but not in the water samples. In this instance, which ecological service is the
marsh providing?
A. coastal land
B. Aquatic habitat
C.Flood protection
D. Water purification
Answers
Answer:
It is D
Explanation:
Trust me I've taken it already, and plus it talks about it not being in the water.
In the given instance, the ecological service which is providing the marsh is the water purification. Thus, the correct option will be D.
What is the Ecological service?
Ecological services or ecosystem services are the many and varied benefits which the humans are provided or get from the natural environment and the healthy ecosystems. Such ecosystems include, for example, the agroecosystems, forest ecosystem, grassland ecosystems, and also the aquatic ecosystems.
A group of researchers are monitoring the health of a salt marsh. They measure high levels of nutrients in the sediment but not in the water samples. In this instance, the ecological service which is providing marsh is the water purification.
Therefore, the correct option is D.
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In humans, dimples are dominant to no dimples and freckles are dominant to no freckles. A man with
no dimples or freckles mates with a woman who is heterozygous for both traits. Determine the
percentage of their offspring that will have the same genotype as their mother. Also determine the
percentage of their offspring that will have the same phenotype as their father.
Answers
Answer:
I'm being honest the answer are in the pdf pls don't report me its not a scam
Explanation:
The correct answer is 25% of their offspring will have the same genotype as their mother.
25% of their offspring will have the same phenotype as their father.
What is genotype?The term genotype refers to an organism's whole complement of genes; in other words, it describes its genetic composition. In a more restricted meaning, the phrase can refer to the alleles, or alternative forms of a gene, that an organism carries.
what is phenotype?A phenotype is just an observable trait. Pheno means observe and is derived from the same root as "phenomenon." As a result, it's an observable sort of organism that can refer to anything from a common characteristic like height or hair color to the presence or absence of a disease.
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When trrowing a ball why does the triceps muscle contract?
Answers
Answer:
The contraction of the triceps muscle causes the arm to flex. The contraction of the triceps muscle causes the arm to extend. When added to the force of the biceps contracting it provides extra force to the ball.
40. The state of matter with definite shape and definite volume
A. Gas
B. Liquid
C. Solid
Answers
Answer:
C. Solid
Explanation:
Gas has no definite shape or volume, and liquid has no definite shape. Hope this helps, best of luck!
Answer:
solid
Explanation:
liquid flow everywhere
gas blow in water
but solid is in fix shape
Which system is responsible for creating red blood cells?
a
skeletal
b
muscular
c
nervous
d
circulatory
Answers
9. When water is ejected from the earth's interior in the form of hot water, it is called
A) Geyser
B) Hot Springs
C) Both (A) and (B)
D) None of the above
10. The efficiency of geothermal plant is about
A) 5%
B) 15%
C) 25%
D) 35%
Answers
When water is ejected from the earth's interior in the form of hot water, it is called a geyser and hot spring. The efficiency of a geothermal plant is about 15%.
Hot springs and geysersHot springs are defined as springs generated by the emergence of heat groundwater onto the Earth's surface.
A geyser is a specific type of spring that ejects heat water, which is accompanied by steam.
In general, these geological formations (geysers) are associated with volcanic areas.
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What does DNA contain?
--------------------------------------------------------------------------------
the ability to translate RNA code
the chromosomes that build proteins
the coded blueprint for life
the factors for heredity called alleles
Answers
Answer and Explanation:
I believe the answer is C. The coded blueprint for life...
Let me know if I'm wrong..
HOW, down to an atomic level is the energy in lighting converted from one form to another.
Give 3-5 sentences
PLEASE HURRY
Answers
Answer:
When properly stimulated, electrons in these materials move from a lower level of energy up to a higher level of energy and occupy a different orbital. Then, at some point, these higher energy electrons give up their "extra" energy in the form of a photon of light, and fall back down to their original energy level.
Explanation:
sorry but I cannot have sentences but all yours
8 In sexual reproduction, an offspring is produced with genes from both parents. When the offspring has a new genetic variation that it got from neither of its parents, it is called. A. an automotive B. a mutation C. a recessive gene D. a phenotype
Answers
Answer: B
Explanation:
Mutations are changes in the DNA sequence that can lead to genetic diversity. Mutations are usually errors in DNA replication or mitosis.
write a paragraph that explains what the causes of Long term climate cycles are. Give examples
Answers
Explanation:
Scientists have predicted that long-term effects of climate change will include a decrease in sea ice and an increase in permafrost thawing, an increase in heat waves and heavy precipitation, and decreased water resources in semi-arid regions.
Below are some of the regional impacts of global change forecast by the Intergovernmental Panel on Climate Change:
North America: Decreasing snowpack in the western mountains; 5-20 percent increase in yields of rain-fed agriculture in some regions; increased frequency, intensity and duration of heat waves in cities that currently experience them.
Latin America: Gradual replacement of tropical forest by savannah in eastern Amazonia; risk of significant biodiversity loss through species extinction in many tropical areas; significant changes in water availability for human consumption, agriculture and energy generation.
Europe: Increased risk of inland flash floods; more frequent coastal flooding and increased erosion from storms and sea level rise; glacial retreat in mountainous areas; reduced snow cover and winter tourism; extensive species losses; reductions of crop productivity in southern Europe.
Africa: By 2020, between 75 and 250 million people are projected to be exposed to increased water stress; yields from rain-fed agriculture could be reduced by up to 50 percent in some regions by 2020; agricultural production, including access to food, may be severely compromised.
Asia: Freshwater availability projected to decrease in Central, South, East and Southeast Asia by the 2050s; coastal areas will be at risk due to increased flooding; death rate from disease associated with floods and droughts expected to rise in some regions
All species of animal have general features in common. Check all of the features that would apply to animals. Check All That Apply Animal cells possess a cell wall and are quite rigid.Animal cells possess a cell wall and are quite rigid. Most animals have the capacity for active movement.Most animals have the capacity for active movement. Animal zygotes undergo mitotic divisions called cleavage.Animal zygotes undergo mitotic divisions called cleavage. Not all animals are multicellular.Not all animals are multicellular. All animals produce diploid spores.All animals produce diploid spores. All animals are heterotrophs.All animals are heterotrophs.
Answers
Answer:
- Most animals have the capacity for active movement
- Animal zygotes undergo mitotic divisions called cleavage
- All animals are heterotrophs
Explanation:
Animals, also known as metazoans, are multicellular eukaryotic organisms from the kingdom Animalia. Animals are a monophyletic group, i.e., all animals are derived from a common ancestor. Animals can be classified into two main groups: 1- invertebrates that don't have a backbone inside their body (e.g., earthworms, octopus, snails, insects, etc) and 2-vertebrates that have a backbone inside their body (e.g., fish, amphibians, reptiles, birds, mammals). Cleavage refers to the division of animal cells in the early embryo. In animals, the zygotic cell divides by mitosis (i.e., cleavage), into smaller cells called blastomeres. Some of the most common characteristics of the animal kingdom are:
- heterotrophy: animals cannot produce their own food and obtain energy by feeding organic material present in other organisms
- generally reproduce through sexual reproduction
- animal's cells do not have cell walls
- they are able to move in almost one stage of their lives
- they can respond to external stimuli by nerve cells and/or muscle cells
You walk up to the crime scene. A dead body is lying on the bank of the river, just a few miles outside of the city. There is a bullet wound on the victim’s chest where it appears a bullet entered the body. There are a few bullets that have been found scattered near the body of the victim. You can see that a gun is resting on the bottom of the river in the shallow end near the shore.
1. Discuss the first things you should teach your new partner to do as you approach the crime scene.
2. Explain how you and your partner should go about handling the gun found at the bottom of the river? What are some things to keep in mind?
3. How should you and your partner go about handling the bullets found near the body of the victim?
4. What information might you be able to find from the gun and bullets found at the crime scene?
5. As we know, it is very important to handle evidence at a crime scene properly. If clues and evidence are mishandled, it could ruin an entire investigation! Conduct some additional online research on your own. Find an article that describes a crime scene where evidence was mishandled. Share the link to the article you found and write a paragraph or two to describe how the scene was mishandled and how this impacted the case. Include advice on how the investigation could have been better managed and how the scene and evidence should have been handled.
Answers
Answer: 1.
As the first responder, you should:
Explanation:
Protect the crime scene.
This means that the first responder should protect the public and the crime scene and also control the changes made to the crime scene to the best of their ability.
Protection of the public means the evacuation of the public from the crime scene to a safer area.
The crime scene should be protected against evidence distortion.
The control of changes made to the crime scene maintains the original evidence present at the crime scene.
2.
Answer:
Fire arm safety measures shall be taken
The gun should not be transported by placing a pencil in the barrel or inside the trigger guard.
There shall be documentation of the location of the gun.
Photos of the location of the gun should be taken.
There after the gun shall be retrieved from the river safely.
Since the gun shall be wet at the time of collection, it shall be kept in a plastic bag.
The gun shall then be transported to the evidence receiving area.
The gun should not be held in the plastic bag for more than two hours since this could lead to the growth of microorganisms which can destroy evidence.
3
Answer:
Things to keep in mind
Fire arm safety mechanisms should be put in place.
Evidence packed in plastic material should not be held in the packing material for more than two hours.
Only large quantities of dry powder should be collected and stored in plastic bags.
Any items which may cross contaminate each other must be packaged separately to avoid evidence contamination
The containers should be closed and secured to avoid the mixture of evidence during the transportation process.
Each container should have:
The collecting person's initials
Date and time it was collected
Complete description of the evidence and where it was found
The investigating agency's name and their file number.
4
Answer
Bullets from near the body of the victim should:
Be packaged separately and placed in paper envelopes or small cardboard pillboxes.
Handled carefully to prevent alter of evidence such as fingerprints.
The bullets have to be submitted to the crime lab for identification of any evidence present on them that could help in investigation.
Be kept safe and separate from the gun.
The container should be labeled to warn that the contents are precautions should be taken to prevent anyone from being injured.
5
Answer:
The gun and bullet might help us out in finding out:
The fingerprints of the user: The gun can be checked to retrieve the fingerprints of its handler if any.
The bullet cartilages shall reveal the owner of the bullets, this shall lead to the identification of a suspect.
Blood, hair that might be found on the gun and bullets might help in DNA analysis. This shall in turn lead us to a suspect.
The guns registration number shall lead us to the owner of the gun used thereby the suspect in the crime.
6
Answer:
The officer who arrested Oscar Pistorius on the night Reeva Steenkamp was killed last year testified Friday that police at the crime scene mishandled evidence, including a ballistics expert who handled the murder weapon without gloves.
This in turn led to confusion in evidence of the case.
The police should have instead used gloves in handling the pistol at the crime scene.
This would have prevented the intoxication of evidence.
Explanation:
Hi there,
What are the three limiting factors involved in photosynthesis???
:D
Answers
Answer:
light intensity, carbon dioxide concentration and temperature.
hope it helps:D
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Answer: light intensity, carbon dioxide concentration and temperature.
Explanation:
An immunodeficiency condition called bare lymphocyte syndrome is caused by a genetic defect that results in an inability to synthesize MHC class II molecules.
a. True
b. False
Answers
Answer:
True
Explanation:
This is because lymphocyte syndrome is a genetic condition where there is absence of or in ability of the cell to express histocompatibility complex class II or MHC class II and this lead to incapability of the immune system to fight infections. The immune system is compromised and weakened to fight infections.
What functions does the red blood cell do for a human?
Answers
Answer: Red blood cells carry oxygen from our lungs to the rest of our bodies. Then they make the return trip, taking carbon dioxide back to our lungs to be exhaled. The function of the red cell and its hemoglobin is to carry oxygen from the lungs or gills to all the body tissues and to carry carbon dioxide, a waste product of metabolism, to the lungs, where it is excreted.
Explanation:
The most common form of hemophilia is a defect in blood clotting factor VIII, which is caused by a mutant form of a gene on the X chromosome. Boys who inherit that mutation from their mother suffer from uncontrolled bleeding. Girls carrying one copy of this mutation have near normal blood clotting. Uncommonly, a girl is born with hemophilia even though both parents have normal phenotypes. Which of the statements might explain hemophilia in a girl born to parents with normal blood clotting phenotypes?
Answers
Answer:
Nondisjunction during sperm arrangement and formation brought about her getting no sex-chromosome from her dad and an X chromosome from her mom, she is XO.
Explanation:
Nondisjunction during sperm arrangement and formation brought about her getting no sex-chromosome from her dad and an X chromosome from her mom; she is XO.
It is on the grounds that her mother happens to be a carrier of hemophilia and she transferred that mutant allele to her daughter and due to the fact that she did not get any sex-chromosome from her dad.
However, such mutant (X) communicates and expresses itself and she is hemophilic.
This (X) is not express in her mother because she possesses a recessive trait; as such it appears in the hom8zygous state.
the direct energy source of cellular respiration is-----------
Answers
Answer:
glucose is the direct energy source of cellular respiration
hope this helps you☺️☺️
Historically, the use of wells appears in the
A) Old Stone Age
B) New Stone Age
C) Bronze Age
D) Iron Age
E) Copper Age
Answers
Answer:
A) Old Stone Age
Explanation:
A mountain range divides a freshwater snail species into two large isolated populations. Erosion eventually lowers the range and brings the two populations together again, but when they mate, the resulting hybrids all produce sterile young. This scenario is an example of:
Answers
Answer:
allopatric speciation.
Explanation:
Reproduction can be defined as a biological process which typically involves living organisms producing an offspring.
Basically, there are two (2) methods of reproduction and these are;
I. Sexual reproduction.
II. Asexual reproduction.
In this scenario, a freshwater snail species is divided into two (2) large isolated populations by a mountain range. This range is then lowered by an erosion and as such bringing the two populations of the freshwater snail species together again.
However, when the two snail species mate, the resulting hybrids all produce sterile young snails. Thus, this scenario is an example of allopatric speciation.
Allopatric speciation is also referred to as geographical speciation and it can be defined as a process in which two (2) biological populations of the same species become isolated from each other by geographical barriers or changes such as mountain range, emigration, etc. Thus, allopatric speciation is dominant with living organisms that reproduces sexually and it causes the isolated species to evolve newly with distinctive traits.
Which is NOT a benefit of xenophyophores in a habitat?
1 They maintain benthic biodiversity.
2 They increase populations of isopods, mollusks, and crustaceans.
3 They churn up sediments that build up on the ocean floor.
4 They convert salt and iron into energy and nutrients.
Answers
The correct answer is 4. They convert salt and iron into energy and nutrients.
Explanation
Xenophiophores are large single-celled organisms generally found deep in the deep sea. They are characterized by being very delicate organisms, which makes it difficult for scientists who intend to study them since they are easily damaged by manipulation. However, in the studies that have been carried out on these organisms, it has been found that they are irreplaceable agents in the sediment deposition process and the maintenance of the biological diversity of benthic organisms. Also, it has been shown that in the areas where these organisms are found there are three to four times more benthic crustaceans, echinoderms, and mollusks than the equivalent areas not inhabited by these organisms. On the other hand, none of these studies has proven that They convert salt and iron into energy and nutrients. Therefore, the correct answer is 4. They convert salt and iron into energy and nutrients.
A young man claiming to be the son of Howard Hughes is suing the estate for his inheritance. Hughes (multimillionaire, inventor, businessman, and subject of the 2004 film, Aviator), did not leave behind any heirs upon his death. The judge overseeing this case, orders blood tests. Howard Hughes has blood type AB, the mother of the young man has type A blood, and the young man had type O. If you were the judge in this case, what would be your ruling?
Answers
Answer:
The young man is not the son of Howard Hughes.
Explanation:
The human blood system works on codominance type of inheritance in the case of blood group A and blood group B present together however, in blood group O it still follows the law of dominance as antigen O is recessive in present of any other antigen.
We know Howard Hughes had blood type AB
So, the genotype would be - IAIB
We also know that the mother of the young man claiming has a blood type A
So, possible genotypes would be - IAIA (case 1) or IAi (case 2)
For case 1,
The possible genotypes for the man claiming would be
IAIB X IAIA --------> IA IA, and IAIB.
According to case 1, he is not the son of Howard.
For case 2,
The possible genotypes for the man claiming would be
IAIB. X I A i ---------> IA IA , IAIB I A i and IB i
Both cases show that the man claiming is not the son of Howard as the blood group of the man is O and the genotype should be ii.
The 2011 earthquake triggered a ... Question 3 options: hurricane volcano tsunami sand storm
Answers
At the equator, what kind of pressure will you most likely find?
Answers
The frequency of genes that lead to favorable traits increases because
A.
favorable traits always start out as the rare form and become more common
B.
the genes for favorable traits are dominant over those for unfavorable genes
C.
Both B and D
D.
those genes continue on to the next generation when the individuals that contain the genes successfully survive and reproduce
Answers
Answer:
The answeer is both B and D.
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List as many examples of seasonal changes of plants and animals that you can.
Answers
Answer:
spring trees bloom flowers
summer trees grow leaves
fall tree lose leaves
winter tree hibernate or something
spring squirrels come out of hibernating
summer squirrels gather food
fall squirrels still gather food and prepare to hibernate
winter squirrels hibernate
Explanation:
barometers modified to measure the height above the sea level are called
Answers
Answer:
When a barometer is supplied with a nonlinear calibration so as to indicate altitude, the instrument is called a pressure altimeter or barometric altimete
Explanation:
Altimeters
An altimeter is a device that measures altitude, the distance of a point above sea level. Altimeters are important navigation instruments for aircraft and spacecraft pilots who monitor their height above the Earth's surface.
How do humans help plants during photosynthesis?
Answers
Answer:
Humans breathe out carbon dioxside which plants need to live and grow during the process of photosynthesis.
Explanation:
They do this by a process known as photosynthesis. ... Photosynthesis and respiration are the two essential processes that allow life to sustain on earth. In a way, they are a cycle — plants help humans breathe by providing us with oxygen, and humans help plants "breathe" by providing them with carbon dioxide.
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Which one ??????????????
Answers
Answer:
It allows genetic variation
Explanation:
what impact does the environment have on the environment?
Answers
Answer:
The environment will impact positively if the human activities are positive and negative if the human activities are negative. It is worthy of note that our actions and activities contribute greatly to the way and manner our environment response to us.
PLEASE HELP !! ILL GIVE 40 POINTS ; PLUS BRAINLIEST !! DONT SKIP ANSWER.
Answers
Answer:
i think its A im sorry if it isnt but im pretty sure its A but it might be wrong
Explanation: